CD Biosynsis

Insights from Literature: Mannheimia succiniciproducens metabolic engineering for succinic acid production

2 months ago08 mins

Succinic acid is a 4-carbon dicarboxylic acid. Not only a major intermediate in the TCA, it is also a major raw material in food, pharmaceutical and chemical production. Since the market for sustainable development is increasing, renewable energy for microbial fermentation of succinic acid is gaining traction in the industry. But old-school fermentation tends to be coupled with…

Improved n-Butanol Production from Clostridium cellulovorans

Insights from Literature: Integrated metabolic and evolutionary engineering to help green production of n-butanol

2 months ago2 months ago010 mins

Driven by the global fossil fuel crisis and environmental issues, the development of biotechnology-based renewable fuels and chemicals has become a research hotspot. As an ideal petroleum alternative, n-butanol has attracted attention due to its superior fuel properties (high energy density, low volatility) and wide range of industrial uses. However, traditional butanol production relies on…

Biosynthetic pathways of L-malic acid in eukaryotes

Insights from Literature: L-Malate Biosynthesis and Metabolic Engineering Strategies

2 months ago05 mins

L-maleic acid is a four carbon dicarboxylic acid found in food, chemical and pharmaceutical industries. L-malic acid is an intermediate in the tricarboxylic acid cycle (TCA), one of the 12 most promising biobased platform chemicals – according to the US Department of Energy. Yet industrial production today mainly depends on chemical production of petrochemical raw materials and…

Application of CRISPR-Cas9 technology in metabolic engineering

2 months ago2 months ago023 mins

Introduction A brief introduction to CRISPR-Cas9 technology CRISPR-Cas9 technology is a revolutionary gene editing tool based on the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system found in bacteria and archaea. This system originally existed as a defense mechanism against phage infection. CRISPR-Cas9 technology uses Cas9 protein and guide RNA (gRNA) to identify and cut…

CRISPR/Cas9 gRNA library screening of functional genes

4 months ago4 months ago010 mins

CRlSPR/Cas9 is an acquired immune system used by bacteria and paleontological bacteria to resist the invasion of genetic material such as foreign plasmids or bacteriophages. The CRlSPR/Cas9 technology was used to establish a mammalian genome-wide mutation library or a gene mutant library related to a certain type of function, and the genes related to the…

Timeline of major events in the development of CRISPR Cas technology and representative Cas9 variants

Application of CRISPR/Cas9 gene editing technology

4 months ago4 months ago020 mins

Gene editing is an emerging genetic engineering technology that can modify specific target genes in the genome of organisms. Gene editing can efficiently perform site-directed genome editing, so it has shown great application prospects in gene research, gene therapy and gene breeding. To date, CRISPR/Cas9 has been widely used in the scientific community as an…

CRISPR/Cas9 genome editing system(Y Cui, et al.,2018)

An in-depth look at CRISPR technology: applications from DNA editing to synthetic biology

4 months ago4 months ago09 mins

CRISPR technology has become the focus of the biotechnology field in recent years, and it has revolutionized the landscape of genetic engineering with its precise, fast and efficient gene editing capabilities. As a revolutionary tool, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has not only accelerated the development of genetic research, but also demonstrated…

CRISPR/Cas Technology: Revolutionizing Viral Research and Vaccine Development

4 months ago4 months ago012 mins

Viral infections pose a significant global health threat, often leading to chronic diseases and the development of resistance to standard antiviral treatments. CRISPR/Cas technology, initially discovered as part of a bacterial immune defense system, is revolutionizing the way scientists study viruses. This innovative tool allows for the creation of viral mutants, detailed gene studies, and…

L-Ergothioneine: The Powerful Antioxidant You Need to Know About

4 months ago4 months ago013 mins

Range of distribution of ergothioneine Ergothioneine is distributed in some tissues and organs of mammals, mainly in red blood cells (about 1~2 mmol. L) and the semen of some animals, although there are no experimental studies showing that animals can synthesize the substance, there is certainly a pathway for the absorption and retention of ergothioneine…

Overview of the four major protein expression systems

6 months ago6 months ago012 mins

The recombinant protein expression technology was established in the early 70s of the 20th century, in which the target gene was introduced into the host cell through a vector, and the target protein was produced with the help of the host’s protein production mechanism. Nowadays, many researchers use prokaryotic or eukaryotic cells such as Escherichia…

The world’s first AI designed and open-source CRISPR gene editor has successfully edited human DNA

Frontier | FDA approved new gene editing therapies for the treatment of OTC deficiency in clinical practice; LSTA1, a new drug for the treatment of osteosarcoma, has been recognized as an orphan drug

Gene editing therapy: Is Base editing and Prime editing technology the future?

Avantium stops its bio based polyol business and focuses on FDCA and PEF!

EU funded project to develop 24 bio based products using enzymes and strains from olive leaves

Ginkgo announces Q3 financial report: $55 million recorded, establishing new partnerships with Pfizer and Google

Spanish researchers have developed the smallest amiRNA that can reduce the cost of RNA pesticides and pave the way for large-scale production

The world’s first gene editing therapy for sickle cell anemia has been approved in the UK, jointly developed by Vertex and CRISPR

Cell: Cas9 can cause chromosome loss. The Nobel Prize team has developed an improvement plan to enhance the clinical safety of gene editing

Utilizing evolutionary diffusion for protein generation, Microsoft’s open-source new protein generation AI framework EvoDiff

《Cell》breaks the world record for yeast! The Miracle of Artificial Life

CRISPR/Cas9 gRNA library screening of functional genes

Insights from Literature: Mannheimia succiniciproducens metabolic engineering for succinic acid production

Insights from Literature: Integrated metabolic and evolutionary engineering to help green production of n-butanol

Insights from Literature: L-Malate Biosynthesis and Metabolic Engineering Strategies

Application of CRISPR-Cas9 technology in metabolic engineering

CRISPR/Cas9 gRNA library screening of functional genes

Application of CRISPR/Cas9 gene editing technology

An in-depth look at CRISPR technology: applications from DNA editing to synthetic biology

CRISPR/Cas Technology: Revolutionizing Viral Research and Vaccine Development

L-Ergothioneine: The Powerful Antioxidant You Need to Know About

Overview of the four major protein expression systems

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MRNA process development and production – mRNA process development – mRNA synthesis and modification

Overview of DNA synthesis technology

Custom miRNA Synthesis: Unlocking Potential in Genetic Research

Saccharomyces cerevisiae efficiently produces the spice raspberry ketone on a chassis, with the highest reported yield currently

Amyris: kilogram level GMP synthesis of semi synthetic vaccine grade squalene

Deep Dive into Phenotype and Genotype

Overview of the four major protein expression systems

Comparison of Pro XylaneTM from different suppliers

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