Research background: Phenylpropanoid compounds such as p-CA are important precursors for the synthesis of various plant secondary metabolites, including stilbenes, flavonoids, and lignans. These compounds have pharmacological significance due to their beneficial health properties. Although it is feasible to extract or chemically synthesize p-coumaric acid from plant raw materials, the use of glucose for…
A synthetic P. putida consortium for simultaneous TPA and EG degradation. In response to the astonishing growth of global plastic pollution, researchers have developed a synthetic microbial ecosystem that can collectively upgrade plastics to the required chemicals. Researchers did not attempt to synthesize a single organism that could complete all the upgrading and recycling steps, but instead…
Pleuromutilin congeners is a broad-spectrum diterpenoid antibiotic produced by Clitopilus passekerianus and related fungi. In order to develop the biotechnology potential of such natural products, it is crucial to fully understand their biosynthetic pathways. Previously, the pathway for biosynthesis of pleuromutilin congeners has been determined (Figure 1). In this article, the author reports two pathways…
Research background Paclitaxel is a well-known anti-tumor natural product. Over the past two decades, an important bottleneck in the early biosynthesis of paclitaxel has been the heterologous expression of cytochrome P450 (including paclitadiene 5) in the biosynthesis pathway α- Hydroxylase (T5 α H) Hybridity of multiple products). These byproducts will metabolize from the precursor taxadien-5…
Sterols have various important physiological functions, and their biosynthesis and function have been fully studied in eukaryotes. However, the synthesis and function of bacterial sterols are relatively poorly explored. There are several bacteria known to produce sterols from scratch, including aerobic methane oxidizing bacteria, floating mold, and various slime bacteria. Unlike eukaryotes, these bacteria mainly…
Raspberry ketone is the main aromatic compound of red raspberry, which has wide applications in cosmetics, food, and medicine. In recent years, raspberry ketone has attracted wide attention as a essence and dietary supplement. However, the natural abundance of raspberry ketone is low, with only 1-4 milligrams extracted from 1 kilogram of raspberry, making…