Frontier technology

With the increasing awareness of environmental issues and sustainability, the demand for products such as environmental protection, high-quality food, and cosmetics is also increasing. At this critical moment, microorganisms become potential key players, providing important solutions for these seemingly completely different problems. Microbial Cell Factory: A Wonderful Revolution   The field of systemic metabolic engineering…

Biomanufacturing technology based on synthetic biology can create novel creations in a flexible and diverse manner that have not been before. However, due to the complexity of biological systems, researchers have to rely on repeated experiments to cultivate and screen engineering microorganisms with superior performance. To reduce the number of experiments and improve the efficiency…

On November 8, 2023, after 15 years, the Synthetic Yeast Genome Project 2.0 (Sc2.0) research team announced a significant milestone: all 16 chromosomes of synthesized yeast, including a newly synthesized tRNA chromosome, have been synthesized, creating a yeast strain containing over 50% synthetic DNA. The relevant achievements have been published in Cell, Molecular Cell, and…

On November 16th local time in the United States, Vertex Pharmaceuticals (Nasdaq: VRTX) and CRISPR Therapeutics (Nasdaq: CRSP) announced that the UK Medicines and Healthcare Products Regulatory Authority (MHRA) has awarded their jointly developed CRISPR gene editing therapy CASGEVY ™ Conditional marketing license for exaagloggene autotemcel for the treatment of sickle cell anemia (SCD) and…

RNA interference (RNAi) based biopesticides are considered a disruptive technology in the field of plant protection in the future, which will greatly change human thinking and strategies for controlling harmful organisms such as agricultural diseases, insects, and grasses. Although it has not yet been widely used, the cost of RNA production is high, and the…

Since the 1990s, the lotion of triterpene squalene ((6E, 10E, 14E, 18E) -2,6,10,15,19,23-hexamethyl-tetraeicosane -2,6,10,14,18,22-hexene, CAS 111-02-4) has been used as an adjuvant of influenza vaccine. Other indications such as tuberculosis, malaria, schistosomiasis and leishmaniasis are being evaluated clinically. Except for aluminum oxide salts, squalene based emulsions are the most commonly used vaccine adjuvants in licensed…

Organisms use enzymes to decompose or synthesize substances under mild conditions, often without relying on toxic compounds or extreme high temperature conditions, making them known as “perfect chemists”. However, due to the complexity and variability of enzyme reaction mechanisms, designing their synthesis is one of the most challenging tasks in biochemistry. On February 22nd, David…

Evolution has produced multiple functional proteins that can precisely regulate cellular processes. In recent years, deep generation models have emerged, aiming to learn from this diversity and generate both effective and novel proteins, with the ultimate goal of customizing functionality to address today’s prominent challenges.   When it comes to creating new proteins on computers,…