In the realm of protein research, few names resonate as deeply as that of David Baker. His significant work has effectively sculpted our understanding of proteins, their complex structures, and their multifaceted functions. This blog aims to delve into Baker’s remarkable contributions, providing an in-depth exploration of his work on protein structure prediction, protein design,…
In the rich and multifaceted realm of biology, there exist two crucial terms that every student, researcher, and biology enthusiast must comprehend – “phenotype” and “genotype”. These twin concepts form the very foundation of genetics, playing a significant role in explaining how traits are passed down from parents to their offspring. This blog post aims…
Introduction The world of non-coding RNAs has sparked considerable interest within the scientific community due to their influential role in the regulation of gene expression. Among these non-coding RNAs, siRNA (small interfering RNA) and miRNA (microRNA) have stood out, attracting significant attention from researchers worldwide. Both these RNA molecules are involved in an important biological…
DNA is a fundamental component of life and a core material in synthetic biology. Synthetic biology is an emerging interdisciplinary field that utilizes engineering principles and techniques to design and construct biological systems with specific functions. The application prospects of synthetic biology are very broad, involving multiple fields such as medicine, agriculture, energy, environment, and…
DNA design and synthesis are key common underlying technologies that drive the development of life sciences and related fields. Conventional genetic manipulation techniques can only make limited modifications to existing DNA sequences, while DNA synthesis techniques can “write” life information from scratch, enhancing our ability to understand, predict, and manipulate living organisms from another perspective….
/01/Trillion imagination The term “synthetic biology” first appeared in the 1970s, until it was redefined by Stanford professor Eric Kool in 2000 by introducing engineering concepts based on genomics and systems biology, marking the emergence of this discipline. Simply put, synthetic biology is the use of engineered organisms such as bacteria to produce various…
Sulfur-containing natural products (sulfur-containing NPs) cover almost every type of NP discovered so far. The source of sulfur in peptide NPs is usually composed of cysteine and methionine. Methionine can be directly incorporated into peptide NPs without any modification, such as precarriebowamide (1). The cysteine residues in peptide NPs are typically embedded in intramolecular disulfides,…
1) Introduction to L-malic acid Malic acid, also known as 2-hydroxysuccinic acid, has an asymmetric carbon hydroxysuccinic acid in its molecule, which has two stereoisomers and exists in three forms: L-malic acid, DL malic acid, and D-malic acid. It can be widely used in fields such as food and beverage, medicine, and chemical industry. Currently,…
The drawbacks of traditional microbial fermentation processes include the risk of contamination by harmful microorganisms, the inhibitory effect of high concentration carbon sources in the culture medium, microbial thermal sensitivity, and instability. And low yield and productivity, low substrate utilization efficiency, production of by-products and secondary metabolites, or high downstream processing costs. In order to…
The definition of synthetic biology is to use engineering ideas to modularize or create biological cells, enabling them to have the ability to synthesize compounds. Generalized synthetic biology actually refers to the extension of a series of downstream technologies based on DNA editing technology, including microbial metabolic engineering, enzyme engineering, gene editing services, cell therapy…