The unique sulfur-based chemical properties of thiols play an important role in the protection of cellular function and components. The body has evolved to rely on highly abundant low molecular weight thiols, such as glutathione (GSH), to maintain redox balance, but also play other important roles, including xenobiotic detoxification and signal transduction. Some of these…
Hydroxypropyltetrahydropyranotriol is the main functional component of Pro Xylane and has multiple possible isomeric configurations. We used HPLC method to compare and analyze the active components of multiple commercially available bosomes, and experimentally verified that the differential isomerization reaction is a condition for their different configurations. The experimental results indicate that the boson generated…
Pleuromutilin congeners is a broad-spectrum diterpenoid antibiotic produced by Clitopilus passekerianus and related fungi. In order to develop the biotechnology potential of such natural products, it is crucial to fully understand their biosynthetic pathways. Previously, the pathway for biosynthesis of pleuromutilin congeners has been determined (Figure 1). In this article, the author reports two pathways…
Research background Paclitaxel is a well-known anti-tumor natural product. Over the past two decades, an important bottleneck in the early biosynthesis of paclitaxel has been the heterologous expression of cytochrome P450 (including paclitadiene 5) in the biosynthesis pathway α- Hydroxylase (T5 α H) Hybridity of multiple products). These byproducts will metabolize from the precursor taxadien-5…
Sterols have various important physiological functions, and their biosynthesis and function have been fully studied in eukaryotes. However, the synthesis and function of bacterial sterols are relatively poorly explored. There are several bacteria known to produce sterols from scratch, including aerobic methane oxidizing bacteria, floating mold, and various slime bacteria. Unlike eukaryotes, these bacteria mainly…
In recent years, there has been a trend in the skincare industry towards “presenting facts and reasoning” ingredients. Blue copper peptides, which have been dormant in the industry for many years, have become active in the public eye, along with their popularity and raw material prices. Since its usability has been explored by many brands…
The Mai brothers we are going to talk about today are not mainstream (mainly because they are expensive). But as everyone delves deeper into the ingredients and its own strength, adhering to the principle of “gold always shines”, Ergothiamine gradually becomes well-known and widely used. So today, I will take everyone together to get to…
Organisms use enzymes to decompose or synthesize substances under mild conditions, often without relying on toxic compounds or extreme high temperature conditions, making them known as “perfect chemists”. However, due to the complexity and variability of enzyme reaction mechanisms, designing their synthesis is one of the most challenging tasks in biochemistry. On February 22nd, David…
Enzymes are a class of highly functional biocatalysts that catalyze chemical reactions through complex active sites, greatly accelerating the reaction process and providing unparalleled selectivity. With the advancement of technologies such as DNA synthesis and sequencing, bioinformatics, and computational modeling, more and more natural enzymes with specific catalytic functions have been discovered. These enzymes have…
Evolution has produced multiple functional proteins that can precisely regulate cellular processes. In recent years, deep generation models have emerged, aiming to learn from this diversity and generate both effective and novel proteins, with the ultimate goal of customizing functionality to address today’s prominent challenges. When it comes to creating new proteins on computers,…