Utilizing evolutionary diffusion for protein generation, Microsoft’s open-source new protein generation AI framework EvoDiff

Evolution has produced multiple functional proteins that can precisely regulate cellular processes. In recent years, deep generation models have emerged, aiming to learn from this diversity and generate both effective and novel proteins, with the ultimate goal of customizing functionality to address today’s prominent challenges.   When it comes to creating new proteins on computers,…

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Saccharomyces cerevisiae efficiently produces the spice raspberry ketone on a chassis, with the highest reported yield currently

Raspberry ketone is the main aromatic compound of red raspberry, which has wide applications in cosmetics, food, and medicine. In recent years, raspberry ketone has attracted wide attention as a essence and dietary supplement.   However, the natural abundance of raspberry ketone is low, with only 1-4 milligrams extracted from 1 kilogram of raspberry, making…

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L-malic acid biosynthesis, the malic acid market is expected to reach a scale of tens of billions by 2031

1) Introduction to L-malic acid Malic acid, also known as 2-hydroxysuccinic acid, has an asymmetric carbon hydroxysuccinic acid in its molecule, which has two stereoisomers and exists in three forms: L-malic acid, DL malic acid, and D-malic acid. It can be widely used in fields such as food and beverage, medicine, and chemical industry. Currently,…

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Cell free biosynthesis system

The drawbacks of traditional microbial fermentation processes include the risk of contamination by harmful microorganisms, the inhibitory effect of high concentration carbon sources in the culture medium, microbial thermal sensitivity, and instability. And low yield and productivity, low substrate utilization efficiency, production of by-products and secondary metabolites, or high downstream processing costs. In order to…

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Overview of Synthetic Biology

Overview of Synthetic Biology

The definition of synthetic biology is to use engineering ideas to modularize or create biological cells, enabling them to have the ability to synthesize compounds. Generalized synthetic biology actually refers to the extension of a series of downstream technologies based on DNA editing technology, including microbial metabolic engineering, enzyme engineering, gene editing services, cell therapy…

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