Abstract Hydrogen sulfide (H2S) is a gaseous microbial metabolite, and its role in intestinal diseases is highly controversial. This is mainly due to the difficulty of accurately measuring H2S and the use of model systems that cannot accurately represent the human intestinal environment for research. In this paper, the engineered Escherichia coli designed by the…
Many microorganisms accumulate compatible solutes to counteract external pressures such as high osmotic pressure, high temperature, drying, and freezing. Among numerous compatible solutes, tetrahydropyrimidine stands out for its significant efficacy in effectively protecting halophilic cells from osmotic pressure imbalance and maintaining the stability of intracellular biomolecules. Recent studies have shown that tetrahydropyrimidine has the potential…
Metabolic engineering refers to the purposeful modification and modification of cellular metabolic pathways using genetic engineering techniques, altering cellular characteristics, and producing specific target products. Metabolic engineering has a history of 30 years since its development. From traditional modification techniques such as knocking out byproduct generation pathways, releasing product synthesis inhibition, and overexpressing key enzymes…
According to a new study by researchers at the University of Michigan, a protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins are effective for specific purposes. This method has profound potential in assembling proteins and peptides, and can be used for applications ranging from industrial tools to therapeutic…
With the continuous intensification of global climate change, environmental pollution and other issues, “clean energy” has become a hot topic on a global scale. As a renewable energy source, clean energy can not only meet the growing energy needs of human society, but also alleviate the current energy crisis and environmental problems to a certain…
L-theanine is a source of fresh and unique flavor in tea, and its content affects the quality and price of tea. theanine has various positive effects on human health, such as antioxidant, anxiety relief, anti-tumor, memory improvement, blood vessel improvement, and immune enhancement. Therefore, L-theanine, as a multifunctional food additive, has attracted much attention due…
Curcumin is a polyphenolic compound with good biological activity. It exists in the plant turmeric and has low water solubility. It has great potential as an antioxidant, anti-inflammatory, anti-cancer and anti diabetes drug. Therefore, curcumin is considered a safe and promising drug that can be used to prevent and treat various diseases. Curcumin is mainly…
1、 Phenylalanine metabolism Phenylalanine (PA) has racemic DL type, L type, and D type. L-type is an essential amino acid for humans and animals, with a molecular weight of 165.2. It belongs to the aromatic amino acid group and mainly participates in the composition of various protein components, which can only be obtained from food….
Introduction: In the vast palette of nature’s creations, melanin stands out as a pigment of remarkable complexity and importance. Found in varying concentrations across living organisms, melanin plays diverse roles, from determining skin color to protecting against harmful UV radiation. This article aims to delve into the fascinating world of melanin, exploring its structure, functions,…
Malonic acid is an important intermediate, and its derivatives have important applications in the fields of medicine, agriculture, chemical industry, and food processing. It can be expressed in Escherichia coli through β- The alanine pathway achieves biosynthesis, with a yield of 3.6 g/L. Fu Wenxuan and others followed the path of phosphoenolpyruvate/pyruvate → oxaloacetic acid…