Introduction The world of non-coding RNAs has sparked considerable interest within the scientific community due to their influential role in the regulation of gene expression. Among these non-coding RNAs, siRNA (small interfering RNA) and miRNA (microRNA) have stood out, attracting significant attention from researchers worldwide. Both these RNA molecules are involved in an important biological…
Glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) are important precursor substances for the synthesis of glycosaminoglycans, with extensive application value in many fields. Microbial fermentation has many advantages in the production of GlcN and GlcNAc, and is increasingly favored. This study constructed genetically engineered strains of Escherichia coli with high production of GlcN and GlcNAc, laying the…
Research background: The biosynthesis of natural products usually requires the binding of eukaryotic cytochrome P450 (P450) to P450 reductase, which is physically close and undergoes electron transfer reactions. Research question: Unfortunately, the functional expression of eukaryotic p450 in bacteria is often still difficult. Research content and results: 1) The author of this article artificially approached…
DNA is a fundamental component of life and a core material in synthetic biology. Synthetic biology is an emerging interdisciplinary field that utilizes engineering principles and techniques to design and construct biological systems with specific functions. The application prospects of synthetic biology are very broad, involving multiple fields such as medicine, agriculture, energy, environment, and…
DNA design and synthesis are key common underlying technologies that drive the development of life sciences and related fields. Conventional genetic manipulation techniques can only make limited modifications to existing DNA sequences, while DNA synthesis techniques can “write” life information from scratch, enhancing our ability to understand, predict, and manipulate living organisms from another perspective….
In daily life, we often see sliced apples being oxidized in the air, and the flesh gradually turns from white to yellow brown. However, our human body also experiences this kind of oxidation. The human body continuously produces free radicals due to continuous contact with the outside world, including respiration (oxidation reaction), metabolism, external pollution,…
Theodor Escherich, an outstanding physician and scientist of the 19th century, was one of the earliest scientists to explore microorganisms. He founded the field of intestinal pathology and associated his name with the name Escherichia coli, which was discovered and named in 1885. From then on, the “E.coli clan” was endowed with the fate of…
In 2011, countries such as the United States, China, the United Kingdom, Singapore, and Australia launched the “Sc2.0 Project” to redesign and synthesize all 16 chromosomes of brewing yeast. This was the first attempt by humans to design and synthesize the genome of eukaryotes from scratch. On November 8, 2023, the latest research findings…
Recently, Tosin Thompson published a news article on Nature titled “How CRISPR gene editing could help treat Alzheimer’s”. Alzheimer’s disease is the most common form of dementia, affecting over 55 million people worldwide. It is expected that this number will nearly double by 2050. Most research on Alzheimer’s disease is driven by the amyloid protein…
Less than a month after the world’s first approval of CRISPR-Cas9 genome editing therapy, this therapy received a second approval – this time from the United States, due to its strict regulation and lucrative healthcare market. The UK regulatory agency approved this therapy on November 16th, which inactivates a gene as a means of treating…