CD Biosynsis

Research background: The biosynthesis of natural products usually requires the binding of eukaryotic cytochrome P450 (P450) to P450 reductase, which is physically close and undergoes electron transfer reactions. Research question: Unfortunately, the functional expression of eukaryotic p450 in bacteria is often still difficult. Research content and results: 1) The author of this article artificially approached…

Theodor Escherich, an outstanding physician and scientist of the 19th century, was one of the earliest scientists to explore microorganisms. He founded the field of intestinal pathology and associated his name with the name Escherichia coli, which was discovered and named in 1885. From then on, the “E.coli clan” was endowed with the fate of…

  In 2011, countries such as the United States, China, the United Kingdom, Singapore, and Australia launched the “Sc2.0 Project” to redesign and synthesize all 16 chromosomes of brewing yeast. This was the first attempt by humans to design and synthesize the genome of eukaryotes from scratch. On November 8, 2023, the latest research findings…

Recently, Tosin Thompson published a news article on Nature titled “How CRISPR gene editing could help treat Alzheimer’s”. Alzheimer’s disease is the most common form of dementia, affecting over 55 million people worldwide. It is expected that this number will nearly double by 2050. Most research on Alzheimer’s disease is driven by the amyloid protein…

Less than a month after the world’s first approval of CRISPR-Cas9 genome editing therapy, this therapy received a second approval – this time from the United States, due to its strict regulation and lucrative healthcare market. The UK regulatory agency approved this therapy on November 16th, which inactivates a gene as a means of treating…

Researchers at the Max Planck Institute of Land Microbiology have developed a synthetic biochemical cycle that directly converts carbon dioxide into the core acetyl CoA. Researchers are able to implement each of these three cycle modules in Escherichia coli, which represents an important step in achieving the synthesis of carbon dioxide fixation pathways in a…