Enzyme-based Therapy

EnzymoGenius™, our advanced enzyme AI design platform, specializes in providing tailored enzyme products and solutions for enzyme-based therapy, exclusively for scientific applications. With a commitment to advancing bioengineering and molecular biology, we offer cutting-edge enzymatic solutions to meet the diverse needs of researchers and scientists in the field.

Introduction to Enzyme-based Therapy

Enzyme-based therapy leverages the biological role of enzymes, working either by amplifying their natural processes or introducing exogenous enzymes to alter physiological conditions. This approach is typically employed when a deficiency or over-activity of a certain enzyme leads to a pathological condition. By regulating enzymatic activity, the therapy bridges the gap created by the dysfunctional enzyme, and thereby curtails the manifestation of symptoms. For instance, enzyme replacement therapy, a subset of enzyme-based therapy, introduces recombinant enzymes into patients suffering from inherited metabolic disorders, known as lysosomal storage diseases. These diseases are caused due to the deficiency of particular enzymes necessary for metabolism.

Fig 1. Therapeutic enzymes. (Tandon S, et al., 2021)

The recombinant enzyme then compensates for the absent or malfunctioning native enzyme, thereby reducing disease severity and improving patient prognosis. The prominence of enzyme-based therapies is incessantly growing, already showing promising results in several clinical trials, and fosters potential in combating rare and chronic diseases.

Applicable Research Areas

• Custom Enzyme Design: Our enzymes are engineered to optimize processes such as DNA replication, transcription, and translation, allowing researchers to fine-tune molecular reactions with unprecedented accuracy.
• Metabolic Disorders: Our customized enzyme products play a crucial role in managing metabolic disorders such as phenylketonuria (PKU) and lysosomal storage diseases, where deficient enzyme activity leads to the accumulation of toxic metabolites.
• Cancer Therapy: Enzyme-based therapies are utilized in cancer treatment to enhance drug delivery, particularly in prodrug activation strategies where enzymes convert inactive compounds into potent cytotoxic agents at the tumor site.
• Neurodegenerative Diseases: Our enzyme solutions support research into neurodegenerative disorders like Alzheimer's and Parkinson's by facilitating the degradation of disease-associated protein aggregates.
• Immune Disorders: Enzymes are essential in immune modulation therapies, assisting in the development of treatments for autoimmune diseases like rheumatoid arthritis and multiple sclerosis.
• Digestive Disorders: Enzyme-based therapies aid in managing digestive ailments such as celiac disease and lactose intolerance, where enzyme supplementation helps alleviate symptoms.
• Rare Genetic Disorders: Our platform caters to research in rare genetic diseases, offering enzyme-based solutions to address the underlying biochemical deficiencies in disorders like Gaucher's disease and Pompe disease.

Our Technical Advantages

In the realm of enzyme-based therapy, CD Biosynsis stands as a beacon of innovation and precision.  With a focus on customization, advanced technologies, and interdisciplinary expertise, we empower researchers and scientists to explore the full potential of enzyme-based therapies in addressing a wide spectrum of diseases. For inquiries and further information, please do not hesitate to contact us.

Reference

1. Tandon, S.; et al. Therapeutic enzymes: discoveries, production and applications. Journal of Drug Delivery Science and Technology. 2021, 63: 102455.