Case Study: AI-Driven Enzyme Engineering Revolutionizes Fabric & Household Care
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CD Biosynsis offer one-stop enzyme discovery and design, manually combined with cutting-edge biotechnologies, nice variety of isolation and purification technologies, high-throughput screening technologies, bioinformatics tools and metagenomic libraries.Our service is available from providing sample preparation to final identification of new enzymes.
Enzyme Discovery and Design (K Steiner, et al., 2012)
We can do more than enzyme discovery, we can also enhance the existing enzyme for your required conditions and optimise their production. For customised enzyme design, high-throughput biochemical screening, protein production and purification, you can utilise E. coli. In attempt to make this process faster and more economical, bioinformatically guided enzyme design will be applied.
We have long-term experience, and all experiments will go through the full steps in accordance with the most advanced experimental protocols and technologies in order to improve efficiency of service and ensure product quality. We endeavour to offer professional consulting services for enzyme engineering such as directed evolution and enzyme activity and kinetics analysis, provide professional customised service in protein purification, and also offer professional design service for protein compatible with liposome.
In addition, our company provides Comprehensive one-stop enzyme discovery and designing services with absolute top-caliber comprehensive solutions for enzyme discovery and optimization and processing.
Strategies for the discovery of new enzyme functions(K Chen, et al., 2020)
The detailed service description is as follows:
Enzyme discovery platform
Based on a high-throughput virtual screening model developed from a 3D model, screen and identify enzyme candidate sequences for possible target enzymes, using the returned set of enzyme candidate sequences as target enzymes to identify screening enzymes that may have chemical reactions associated with your desired compound library that will produce the required new molecules.
Enzyme engineering and optimization
Based on the thought of rational design, directed evolution and other methods, we have constructed the new proteins that have higher efficiency to catalyze reactions and endowed the traditional proteins with features such as high activity and thermostability, which enhanced the feasibility of industrial application. Adapted by an expert team with rich experience, we have a broad class of methods to build various models and facilitated the development of validation events of enzyme engineering.
Enzyme expression and purification
We offer customised enzyme design, high-throughput production and purification based on Escherichia coli according to the advanced gene synthesis and protein production technology, which keeps it flexible in quickly finding and producing needed enzymes.
Experimental testing of activity and specificity of enzymes
Experimental testing of enzyme acitivty and specificity is done in a number of ways.
Enzyme production
Including large-scale production and process development of recombinant proteins and enzymes
Customer cooperation with the company's 'one-stop enzyme discovery and design services' can include the following steps:
Needs analysis and project initiatioanl
Stages of the sales process
Signing contract
Project execution
Delivery and acceptance of results
Follow up service and technical assistant
Customer background: A scientific research institution needs a new enzyme with excellent catalytic properties.
Solution: We used genome mining technology to obtain a new type of R-mandelate dehydrogenase with excellent catalytic properties, and conducted research on related enzymatic characteristics. Through subsequent efficient expression and rational transformation, the biosynthesis of acetophenone acid was successfully realized.
Results: This research not only laid the foundation for subsequent efficient expression and transformation, but also provided new tools and methods for related biosynthetic pathways.
Production of daily chemicals
Enzyme catalysis is very beneficial for production of daily chemicals. By designing and optimisation of the enzyme, we can improve production efficiency and product quality.
Drug synthesis
Enzymes can be widely used in the pharmaceutical and biochemical industries as high selective and high specificity biocatalys. The use of enzymology design and modification approach may shorten the R ․ D period for new drugs, and also improve the efficiency and safety of drug production.
Food industry
Enzymes are extremely useful in the food industry because they can be used for optimisation of fermentation processes and for enhancement of food quality and stability as well as their nutritional value. Designer enzymes could be part of the culinary innovation and industry development.
Food industry
Enzymes are extremely useful in the food industry because they can be used for optimisation of fermentation processes and for enhancement of food quality and stability as well as their nutritional value. Designer enzymes could be part of the culinary innovation and industry development.
Green biocatalysis
The usage of enzymes of green biocatalysis contributes to the target sustainable development. We can design and optimise the enzymes to specifically decrease environmental impacts and enhance the utilisation efficiency of resources.
Industrial biotechnology
Enzyme preparations formed the basis of industrial-biotech's rise, through which enzymes were designed and optimised to reduce cost and increase the robustness and yield of industrial processes.
Questions that customers could ask about One-stop Enzyme Discovery and Design Services, and the answers to these questions:
Q: What are enzyme discovery and design services?
A: Enzyme discovery and design services offer complete biotechnology solutions to obtain new enzymes by screening from nature or engineer known enzymes to enhance activity, thermal stability and etc.
Q: What information do we need to provide to start this service?
A: What specific needs do you have? What enzyme are you hoping to improve? What is the intended area of application? Do you have any aspect preferences – for example, time limit or budget? Based on your information, we can devise customised service proposals.
Q: How long will it take to find suitable candidates and then optimise those who are screened?
A: As long as it takes to identify the right two electrodes, the right photograph, and to ensure that they are connected in the most efficient way – sometimes only a few months from screening to optimisation. We'll follow your schedule, however, so no one will be waiting around.
Q: What results can we expect?
A: We want to create enzymes with properties that are better than natural enzymes – let's say with greater catalytic efficiency, greater thermal stability, greater substrate specificity … Then, let's add something that is going to improve the performance of the enzyme for those biotechnology processes.
Q: How to establish effective communication with your company?
A: Communication with customers is very important. It is suggested to arrange meeting time regularly, give feedback on work progress in time, and make sure of the work scope and workload through the work scope and workload diagram so as to ensure the normal course of work.
Q: How difficult would it be if we needed to change partners?
A: Switching partners also can be a bit difficult, if the project is reaching critical stages and the progress needs to be protected. We will do our best to help you to evaluate the current project stage to make it as easy as possible to transfer the project over to you.
Q: What are the specific advantages of your service?
A: We focus on our service advantage of being a one-stop solution which saves customer time and cost on switching different suppliers, and our experienced team with cutting-edge technology can complete every process from enzyme discovery to design in time.
Q: What is your service charge?
A: Our charging will depend on the complexly of the project, our customers' needs. We will send out quotations after our initial consultation.
By answering these questions, as well as more technical ones that help customers come to grips with the technology we provide, our potential clients now have a better sense of how we can work together.
Choose us, and an efficient, professional and complete enzyme discovery and design service partner will be yours. Welcome to work together to make promote the development of science research and the drug research. In case of any requirements or questions, feel free to contact us.
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