Predicting Critical Catalytic Residues through Evolutionary Trace

CD Biosynsis is a leading expert in the field of enzyme design and evolution, with a long and in-depth experience in enzyme directed evolution. Our dedicated team utilizes evolutionary trace analysis to extract key information from enzyme sequences, providing valuable insights for the rational design of enzymes with improved properties or novel functions.

Overview

Evolutionary trace is a method for identifying functionally important residues in proteins. It closely links the sequence variation to the evolutionary differences, as the differences between different sequences are matched to their functional differences. In other words, evolutionary trace is actually a quantitative test for sequence differences versus functional differences. The functionally important residues in proteins are often conserved during evolution, so we are able to leverage the evolutionary trace method, which allows us to analyze a diverse set of related protein sequences to identify their conserved sequences and predict the functional significance of specific residues.

Fig 1. The evolutionary trace model. (Novikov IB, et al., 2020)

Our Advantages

• Professional Scientific Team
  We have a professional research team of scientists with decades of experience in the field of enzyme design and evolution, focusing on the directed evolution and rational design of enzymes, and are committed to providing the greatest impetus for enzyme biology research.
• AI-assisted Development and Design
  Combined with our advantage in AI applications, our EnzymoGenius™ platform enables the application of AI-assisted modeling to evolutionary trace methods, resulting in a powerful increase in predictive efficiency.
• High-quality Services
  We have a team of highly skilled and experienced scientists with in-depth knowledge of enzyme design evolution, who can provide you with professional consulting services before the project and reliable support services after the sale.

CD Biosynsis strives to offer comprehensive and reliable enzyme evolution trace analysis for various applications, whether academic research, industrial applications, or biotechnological development, our services are tailored to meet your specific requirements. Contact us today to learn more about our enzyme evolutionary trace analysis services and how they can benefit your research or development projects. Our team is ready to assist you and provide the insights you need to achieve your goals.

Reference

1. Novikov, IB.; et al. An Evolutionary Trace method defines functionally important bases and sites common to RNA families. PLoS Comput Biol. 2020, 16(3):e1007583.