ABCB4 Knockout cell line （IPSC）

The ABCB4 Knockout cell line (iPSC) is primarily utilized in research focused on drug metabolism and hepatobiliary diseases This product excels in enabling scientists to study the role of ABCB4 in lipid transport particularly in the context of cholestasis and liver function It has significant applications in pharmacological screening where researchers assess the impact of various compounds on bile acid transport and liver health

In experimental workflows researchers can implement the ABCB4 knockout iPSC by differentiating them into hepatocyte-like cells allowing for in vitro modeling of liver disorders These cells can be exposed to drugs or toxins to evaluate cellular responses making it a powerful tool for preclinical studies The practical benefit of using this cell line lies in its ability to mimic human liver conditions enabling more accurate predictions of drug effects and toxicity which enhances the drug development pipeline Additionally specialized techniques such as CRISPR/Cas9 gene editing and quantitative PCR are often employed to validate the knockout efficiency and analyze gene expression profiles ensuring robust research outcomes