CD Acetylcholinesterase Inhibitor Screening Kit

Catalog Number: AKBA281

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$1197

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Product Information
Product Name	CD Acetylcholinesterase Inhibitor Screening Kit
Applications	For evaluation and high-throughput screen (HTS) of acetylcholinesterase modulators.
Features	Fast and sensitive. Linear detection range from 10 to 600 U/L for a 10-minute reaction at room temperature. High-throughput. Homogeneous “mix-incubate-measure” type assay. Can be readily automated on HTS liquid handling systems for processing thousands of samples per day.
Detection Method	OD412nm
Sample Type	Compounds that affect acetylcholinesterase activity
Species	All
Assay Time	30 min
Expiration Date	12 months
Description	ACETYLCHOLINESTERASE (EC 3.1.1.7, AChE), also known as RBC cholinesterase, is found primarily in the blood and neural synapses. AChE catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Inhibition of the enzyme leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. AChE inhibition is an important target for the management of Alzheimer’s disease. In addition to Alzheimer’s disease, AChE inhibitors have been useful in the diagnosis or treatment of diseases such as glaucoma, myasthenia gravis, bladder distention, and more. CD Acetylcholinesterase Inhibitor Assay is based on an improved Ellman method, in which thiocholine produced by the action of acetylcholinesterase forms a yellow color with 5,5′-dithiobis(2-nitrobenzoic acid). The intensity of the product color, measured at 412nm, is proportionate to the enzyme activity in the sample.
Shipping Conditions	Shipping: RT
Storage	Storage: -20°C upon receipt

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