CD Arginase Inhibitor Screening Kit

Catalog Number: AKBA169

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$837

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Specifications

Product Information
Product Name	CD Arginase Inhibitor Screening Kit
Applications	For evaluation and high-throughput screen (HTS) of arginase modulators.
Features	Safe. Non-radioactive assay. High-throughput. Homogenous “mix-incubate-measure” type assay. Can be readily automated on HTS liquid handling system. Rapid and reliable. Can be completed in less than 2 hours and no 37°C heater is needed.
Detection Method	OD430nm
Sample Type	Compounds that affect arginase activity
Species	All
Assay Time	1 hour 45 min
Expiration Date	12 months
Description	ARGINASE (L-arginine ureohydrolase EC 3.5.3.1) is present in mammals and plants. In humans, arginase is expressed predominantly in the liver, and to lesser degrees in the breast, kidney, testes, salivary glands, epidermis and erythrocytes. Arginase catalyzes the conversion of arginine to ornithine and urea, important for protection against NH3 toxicity and for cell growth and repair. Excessive arginase activity has been linked to cardiovascular diseases and also contributes to vascular structural problems and neural toxicity. Studies show that arginase inhibitors have been proven to be beneficial in cardiovascular and nervous system diseases. Simple, direct, and automation-ready procedures for measuring arginase inhibition are highly desirable in Research and Drug Discovery.BioAssay Systems’ arginase inhibitor screening kit provides a sensitive and convenient method to screen for arginase inhibitors. The method utilizes a chromogen that forms a colored complex specifically with urea produced in the arginase reaction. The intensity of the color is directly proportional to the arginase activity in the sample. Percent inhibition of a test compound can be determined by comparing the color intensity of the reaction preincubated with the test compound with the color intensity of an untreated control reaction
Shipping Conditions	Shipping: RT
Storage	Storage: -20°C upon receipt

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