CD Farnesyltransferase Inhibitor Screening Kit

Catalog Number: AKBA213

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$1107

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Specifications

Product Information
Product Name	CD Farnesyltransferase Inhibitor Screening Kit
Applications	For high-throughput screening of FTase inhibitors and evaluation of drug modulators.
Features	Safe. Non-radioactive assay. Homogeneous and convenient. “Mix-incubate-measure” type assay. No wash and reagent transfer steps are involved. High-throughput. A Z’-factor of 0.8 and higher is routinely observed in a 384-well format. Can be readily automated to assay thousands of samples per day.
Detection Method	FL340/550 nm
Sample Type	Compounds that affect farnesyltransferase activity
Species	All
Assay Time	60 min
Limit of Detection	NA
Expiration Date	6 months
Description	FARNESYLTRANSFERASE (FTase, EC 2.5.1.58) catalyzes the transfer of a farnesyl group from farnesyl pyrophosphate to the cysteine residue of the C-terminus of target proteins. When not properly regulated, farnesylated proteins, including the Ras superfamily of small GTPases, can lead to developmental disorders and cancer. Simple, direct and high-throughput inhibitor screening assays find wide applications for oncology research. BioAssay Systems’ EIFT-400 assay kit provides a convenient fluorimetric method to screen for potential FTase inhibitors. In this assay, FTase reacts with farnesyl pyrophosphate and a dansyl-peptide substrate with measurable fluorescence at λem/ex = 340/550 nm. Inhibition is determined by the decrease in fluorescence.
Shipping Conditions	Shipping: Ice
Storage	Storage: -20°C upon receipt.

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