Cell-Free Synthetic Biology

CD Biosynsis offers customized cell-free synthetic biology solutions to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to Cell-Free Synthetic Biology

Synthetic biology integrates different engineering disciplines. Through the engineering and mastery of biological parts, novel biological systems can be created for a wide range of applications. In recent years, the field of synthetic biology has grown exponentially and is poised to transform biotechnology and medicine. Synthetic biology is encountering more and more challenges along with its increasing applications, such as the delivery of genetic material into cells and the optimization of genetic circuits. Some of the innate characteristics of cell-free systems make them compelling platforms that can be used to simplify and avoid many of the pitfalls of synthetic biology.

The cell-free system bypasses the cell wall, removes genetic regulation, and enables direct access inside the cell. It offers the flexibility to explore beyond the confines of living cells by recapitulating gene expression systems in vitro and allows networking of natural and synthetic systems. Cell-free systems provide simpler and faster engineering solutions as well as a versatile test-bed. The unprecedented level of control and freedom of design in an open environment, compared to cell-based approaches, has stimulated the rapid development of engineering foundations for cell-free systems in recent years. Numerous highly active cell-free platforms have now been successfully developed and hold promise to be a powerful tool for synthetic biology in years to come. Cell-free synthetic biology is emerging as a powerful and flexible enabling approach aimed to understand, harness, and expand the capabilities of natural biological systems without using intact cells. It has reached broad research communities both in academia and industry.

Figure 1. Cell-free synthetic biology reaction formats and strategies. (Kelwick R J R, et al., 2020)

Applications

Our Solutions

CD Biosynsis offers integrated cell-free synthetic biology solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their synthetic biology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Kelwick R J R, et al. Biological materials: the next frontier for cell-free synthetic biology. Frontiers in Bioengineering and Biotechnology, 2020, 8.
2. Perez J G, et al. Cell-free synthetic biology: engineering beyond the cell. Cold Spring Harbor perspectives in biology, 2016, 8(12): a023853.

Please note that all services are for research use only. Not intended for any clinical use.