Collagen Strain Engineering

CD Biosynsis harnesses advanced synthetic biology techniques to craft and generate premium collagen. This indispensable protein assumes a central role in a plethora of sectors, encompassing cosmetics, pharmaceuticals, and the realm of regenerative medicine. Our offering furnishes a dependable and eco-conscious reservoir of collagen, thereby transforming the conventional methods of procurement and application.

Background

Collagen stands as an indispensable structural protein within the extracellular matrix of diverse tissues, encompassing the likes of skin, bones, tendons, and cartilage. Its pivotal function revolves around upholding tissue integrity, bestowing resilience, and expediting tissue mending. The hallmark of collagen rests in its unparalleled triple-helical configuration, comprising three polypeptide chains recognized as alpha chains. These alpha chains exhibit a wealth of amino acids, notably glycine, proline, and hydroxyproline, all of which contribute significantly to the distinctive attributes inherent to collagen.

Fig 1. Intracellular collagen biosynthesis and extracellular maturation of collagen I. (Onursal C, et al., 2021)

Collagen biosynthesis encompasses the intricate mechanism through which living organisms fabricate collagen molecules. This phenomenon undergoes meticulous regulation and entails a sequence of enzymatic reactions coupled with post-translational modifications. The foremost objective underpinning collagen biosynthesis resides in securing the accurate assembly of collagen molecules, thereby empowering them to execute their designated structural and functional duties within the organism's framework.

Collagen Biosynthesis Pathway

Types of Collagen We Can Biosynthesize

Our synthetic biology technology allows for the biosynthesis of various types of collagen to meet diverse research and commercial needs. These include, but are not limited to:

Our Technical Advantages

• Gene Customization: We create collagen genes tailored to specific requirements and optimize their genetic makeup for superior performance.
• Host Selection: We choose the ideal microorganisms or mammalian cells as hosts for collagen production, enhancing efficiency.
• Bioreactor Expertise: Our cutting-edge bioreactor systems enable large-scale collagen production, optimized for both yield and purity.
• Purification Methods: Advanced chromatography and filtration methods ensure the isolation and purification of high-quality collagen.

In an era of increasing demand for sustainable and customizable collagen, our collagen biosynthesis service is at the forefront of innovation. We provide tailored solutions for various industries, from cosmetics to regenerative medicine, offering high-quality collagen that meets your specific needs. Contact us today to explore how our advanced technology can transform your projects and products.

Reference

1. Onursal, C.; et al. (2021) Collagen Biosynthesis, Processing, and Maturation in Lung Ageing. Frontiers in Medicine. 2021, 8:593874.

Please note that all services are for research use only. Not intended for any clinical use.