Custom RNA oligos synthesis

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Custom RNA oligos are synthetic RNA molecules that are designed and synthesized according to specific customer requirements. These oligos play a crucial role in various applications such as gene expression studies, RNA interference, and drug discovery. With our custom RNA oligos, you can accurately target and manipulate RNA molecules to gain insights into gene expression patterns, study the function of specific genes, and develop novel therapeutic approaches.

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Service Offered Service Process FAQs

Service Offered

Here's a table outlining different types of RNA Oligos, their applications, and brief application descriptions:

Type of RNA Oligo	Applications	Application Description
siRNA (Small Interfering RNA)	- Gene silencing - Functional genomics	- Induces mRNA degradation or translational repression through the RNA-induced silencing complex (RISC).
miRNA (MicroRNA) Mimics	- Functional studies - Therapeutic development	- Introduces synthetic miRNA to mimic endogenous miRNA, allowing for the study of miRNA functions.
Antisense Oligonucleotides (ASOs)	- Gene therapy - Genetic disorders - Cancer treatment	- Modulates gene expression by specifically binding to target mRNA, influencing translation or stability.

Service Process

Our service process is designed to ensure a seamless and hassle-free experience for our customers. Here is an overview of the steps involved:

Consultation: We start by understanding your research requirements and discussing the details of your custom RNA oligos. Our team of experts will work closely with you to gather all the necessary information and provide personalized recommendations based on your specific needs.
Design and Synthesis: Once we have a clear understanding of your requirements, our team will design the RNA sequence based on your specifications. We use cutting-edge computational tools and algorithms to optimize the sequence for stability, specificity, and desired functionality. The custom oligos are then synthesized using state-of-the-art equipment and techniques.
Quality Control: Quality is our top priority, and each oligo undergoes rigorous quality control checks to ensure accuracy and purity. We employ various analytical techniques to verify the integrity, length, and purity of the synthesized oligos. Only the oligos that meet our strict quality standards are selected for further processing.
Delivery: We understand the importance of safe and efficient delivery of your custom RNA oligos. We take utmost care in packaging the oligos to ensure their stability during transportation. Whether you need the oligos delivered to your laboratory or any other specified location, we work with reliable shipping partners to ensure timely delivery.

FAQs

We understand that you may have some questions regarding our custom RNA oligo services. Here are some commonly asked questions along with their answers:

Q: What is the typical turnaround time for custom RNA oligos?

A: Our standard turnaround time for custom RNA oligos is [insert specific turnaround time]. However, we understand that some experiments may require faster delivery. That's why we also offer expedited options for urgent orders. Please contact our team for more information on expedited services.

Q: Can you provide modifications or labeling for the RNA oligos?

A: Yes, we offer a variety of modifications and labeling options to suit your experimental needs. Our range of modifications includes but is not limited to stability-enhancing modifications, functional group modifications, and modifications for conjugation purposes. We also provide various labeling options such as fluorescent dyes, biotin, and other tags. Our team of experts can guide you in selecting the most suitable modifications and labeling strategies for your specific research goals.

Q: What is the recommended storage condition for the custom RNA oligos?

A: To maintain the stability and integrity of the custom RNA oligos, we recommend storing them at -20°C or below. Storing the oligos at low temperatures helps prevent degradation and ensures their functionality over an extended period. Additionally, we provide detailed storage instructions with each shipment to help you optimize the storage conditions.

Q: Do you provide technical support for using the custom RNA oligos?

A: Absolutely! We believe in providing comprehensive support to our customers. Our team is available to provide technical support and answer any questions you may have regarding the usage of our custom RNA oligos. Whether you need assistance in experimental design, troubleshooting, or data analysis, our experts are here to help you achieve your research goals effectively and efficiently.

Q: Can you provide custom RNA oligos with modified backbone structures?

A: Yes, we offer custom RNA oligos with modified backbone structures. These modifications can enhance stability, resistance to nuclease degradation, and other desired properties. Our team can work with you to determine the most appropriate backbone modifications for your specific research needs.

Q: Is it possible to order custom RNA oligos with specific purification options?

A: Absolutely! We understand that different research applications may require varying levels of purity. We offer a range of purification options, including standard desalting, HPLC purification, and PAGE purification. Our team can assist you in selecting the purification method that best suits your experimental requirements.

Q: Can you provide custom RNA oligos with specific modifications for RNA interference (RNAi) studies?

A: Yes, we specialize in providing custom RNA oligos for RNA interference studies. We offer modifications such as 2'-O-methyl, phosphorothioate, and locked nucleic acids (LNAs) to enhance stability and promote efficient gene silencing. Our experts can guide you in selecting the most suitable modifications for your RNAi experiments.

Q: What is the recommended concentration for working with custom RNA oligos?

A: The recommended concentration for working with custom RNA oligos can vary depending on the specific application. However, a commonly used concentration range is 10-100 nM for most experiments. It is important to optimize the concentration based on your experimental setup and desired results. Our team can provide additional guidance based on your research goals.

We hope these FAQs address some of your concerns. If you have any further questions or if there's anything else we can assist you with, please feel free to reach out to our team.

Please note that all services are for research use only. Not intended for any clinical use.

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