Folate Strain Engineering

Our folate biosynthesis service is a cutting-edge offering tailored exclusively for scientific research purposes. CD Biosynsis specializes in providing expert technical services that facilitate the acquisition of folate, a crucial component in various biological processes.

Background

Folate, also known as vitamin B9, plays a pivotal role in numerous biological processes, particularly in nucleotide synthesis, methylation reactions, and amino acid metabolism. This essential water-soluble vitamin is crucial for DNA synthesis, repair, and cell division. Given its fundamental role in cellular processes, the study and manipulation of folate biosynthesis pathways hold great significance in the field of biotechnology.

Fig 1. Folate biosynthesis in higher plants. (Gorelova V, et al., 2019)

Folate biosynthesis refers to the intricate process by which living organisms synthesize folate de novo within their cells. This process is crucial for maintaining an adequate supply of folate, as many organisms, including humans, cannot produce it directly and rely on dietary sources. For biotechnology companies, understanding and harnessing folate biosynthesis pathways have broad applications, from the development of fortified foods to the production of pharmaceuticals and biofuels.

Folate Biosynthesis Pathway

The folate biosynthesis pathway involves a series of enzymatic reactions that culminate in the production of tetrahydrofolate (THF), the active form of folate. This pathway is highly conserved across various organisms, with minor variations in enzymes and intermediates. Here are the key steps involved in folate biosynthesis:

How We Can Help

As a leading biotechnology company specializing in folate biosynthesis services, CD Biosynsis offers cutting-edge solutions to support research, development, and production processes related to folate. Our comprehensive technology portfolio includes:

• Metabolic Engineering. We employ advanced metabolic engineering techniques to enhance folate biosynthesis in microorganisms, enabling increased production yields for various applications.
• Strain Development. Our experts can design and optimize microbial strains to produce folate efficiently, making it cost-effective for commercial purposes.
• Analytical Services. We provide state-of-the-art analytical services for quantifying folate and its intermediates, ensuring precise monitoring and quality control throughout the production process.
• Pathway Modification. We can tailor folate biosynthesis pathways to meet specific industrial needs, such as the production of biofortified foods or pharmaceutical intermediates.

Incorporating our folate biosynthesis service into your research endeavors ensures access to high-quality, biologically active folate, empowering you to make significant scientific breakthroughs. Contact us today to discuss your needs and discover how we can accelerate your research. Together, we can drive innovation and advance the frontiers of scientific knowledge.

Reference

1. Gorelova, V.; et al. Evolution of folate biosynthesis and metabolism across algae and land plant lineages. Scientific Reports. 2019, 9(1).

Please note that all services are for research use only. Not intended for any clinical use.