Strain Gene Silencing

Gene silencing is a rapidly growing field in synthetic biology that involves the manipulation of gene expression through the use of RNA interference (RNAi) or synthetic RNA silencing. This approach has enormous potential for the development of new therapeutics and the treatment of diseases caused by genetic abnormalities.

CD Biosynsis specializes in providing cutting-edge services for gene silencing, leveraging our expertise in synthetic biology and RNA interference to offer customized solutions for our clients. Our services are designed to help researchers and pharmaceutical companies develop new drugs and therapies that target specific genes or gene pathways.

Fig 1. Schematic Representation of the fast assembly of multiplex siRNAs (FAMsi) System. (He F, Ni N, et al. 2020)

Our Services for Gene Silencing

RNA Interference (RNAi)

RNA interference (RNAi) is a powerful tool for gene silencing that involves the use of small interfering RNAs (siRNAs) to target specific genes or gene pathways. At CD Biosynsis, we offer a wide range of RNAi services, including:

- siRNA design and synthesis

- siRNA screening and optimization

- siRNA delivery systems

- In vitro and in vivo RNAi studies

Our team of experts has extensive experience in the design and synthesis of siRNAs and can work with clients to develop customized siRNA sequences that are optimized for maximum efficiency and specificity. We also offer a range of delivery systems, including lipid-based nanoparticles, to ensure effective delivery of siRNAs to target cells.

Synthetic RNA Silencing

In addition to RNAi, CD Biosynsis also offers synthetic RNA silencing services. Synthetic RNA silencers are a novel class of antibacterials that can be used to combat antibiotic resistance in bacteria. Our team of experts has extensive experience in the design and synthesis of synthetic RNA silencers and can work with clients to develop customized sequences that target specific bacterial genes or pathways.

Gene Editing

Gene editing is another powerful tool for gene silencing that involves the use of engineered nucleases to modify or delete specific genes or gene pathways. At CD Biosynsis, we offer a range of gene editing services, including:

- CRISPR-Cas9 gene editing

- Zinc finger nucleases (ZFNs)

- Transcription activator-like effector nucleases (TALENs)

Our team of experts has extensive experience in the design and synthesis of engineered nucleases and can work with clients to develop customized gene editing strategies that target specific genes or gene pathways.

Our Advantages

• Customized solutions. Our team of experts has extensive experience in synthetic biology and gene silencing and can work with clients to develop customized strategies that meet their specific needs.
• Advanced sequencing technologies and cutting-edge equipment that allow us to provide high-quality services with fast turnaround times.
• Customer service ensure that our clients receive the highest level of service and support throughout the gene silencing process.

Gene silencing is a rapidly growing field in synthetic biology that has enormous potential for the development of new therapeutics and the treatment of diseases caused by genetic abnormalities. CD Biosynsis specializes in providing cutting-edge services for gene silencing, leveraging our expertise in synthetic biology and RNA interference to offer customized solutions for our clients.

Whether you are working on a research project or developing a new therapeutic, our team of experts can work with you to develop customized strategies that meet your specific needs. Contact us today to learn more about our gene silencing services and how we can help you achieve your research goals.

References

1. Dykxhoorn, D., Novina, C., et al. Killing the messenger: short RNAs that silence gene expression. Nature Reviews Molecular Cell Biology 4, 457–467 (2003). https://doi.org/10.1038/nrm1129
2. He F, Ni N, et al. FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells. Molecular therapy. Nucleic acids. 22, 885-899 (2020). doi:10.1016/j.omtn.2020.10.007
3. Good, L., Stach, J. E. M. Synthetic RNA silencing in bacteria – antimicrobial discovery and resistance breaking. Frontiers in Microbiology, 2, 185 (2011).

Please note that all services are for research use only. Not intended for any clinical use.