Genetic Circuit Design

CD Biosynsis provides professional genetic circuit design services for synthetic biology researchers around the world to facilitate their cutting-edge research. We provide tailored solutions and powerful tools to bring diverse synthetic applications and creative ideas to fruition.

Introduction to Genetic Circuit

Synthetic biology is a field of science that deals with engineering and redesigning biological systems. The design of genetic circuits is inspired by electronics and computer science. Genetic circuits can perform logical functions mimicking those observed in electronic circuits and exhibit control over the flow of information in biological systems. Genetic circuit design should follow the principles of modularity, orthogonality, predictability, and reliability.

In recent years, progress in genetic engineering makes it possible to construct novel genetic circuits with different functions and activation mechanisms. Moreover, the development of new tools, including high-throughput DNA assembly and characterization, computer-aided design, and design automation software, enables rapid and automated design and assembly of genetic circuits. These have the potential to accelerate the design of larger gene circuits, thereby increasing our understanding of circuits and host behavior.

Figure 1. Example architectures of artificial genetic circuits. (Sayut D, et al., 2007)

Applications of Genetic Circuit

Featured Technologies

• Computer-aided design—Allow efficient transition from general design to a final product.
• Design automation—Use a category of software tools for designing systems with a target behavior.

Service Offering

• Design of input modules, such as protein-based molecules and RNA, to recognize and transmit diverse signals.
• Design of operation modules, such as transcriptional, posttranscriptional, and biostable gene switches, to intervene and control the expression of the output module at different levels.
• Design of output modules, such as fluorescent proteins, selection markers, and metabolic enzymes, whose synthesis is determined by operation modules in response to specific input signals.
• Design of biological logic gates (YES, No, AND, OR, NAND, and NOR) by the combination of input, operation, and output modules.
• Design of genetic oscillators to regulate gene expression that relies on precise timing.

CD Biosynsis offer a variety of cutting-edge techniques to tailor genetic circuit design services for individual customer specifications. We have an experienced scientific team of biologists, bioinformatics, and chemists to help execute innovative designs for unique applications.

We are also available for on-demand customer assistance via email or phone to help you with any problems or concerns you may have. If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

1. Sayut D, et al. Engineering and applications of genetic circuits. MOLECULAR BIOSYSTEMS-ELECTRONIC EDITION-, 2007, 3(12): 835.
2. Brophy J A N & Voigt C A. Principles of genetic circuit design. Nature methods, 2014, 11(5): 508-520.
3. Mukherji S & Van Oudenaarden A. Synthetic biology: understanding biological design from synthetic circuits. Nature Reviews Genetics, 2009, 10(12): 859-871.

Please note that all services are for research use only. Not intended for any clinical use.