Genome Design

CD Biosynsis provides professional genome design services for synthetic biology researchers around the world to facilitate their cutting-edge research. We provide tailored solutions and powerful tools to bring diverse synthetic applications and creative ideas to fruition.

Importance of Genome Design

With the rapid development of genome sequencing, bioinformatics, and DNA design programs, as well as the reduced gene synthesis costs, synthetic biology has become a readily applied approach to creating new biological systems. Rapid technological advances have enabled the design and construction of entire genomes. Large-scale genome design and reconstruction is a direct test of the authenticity, integrity, and accuracy of current biological knowledge. It is very important for the systematic evaluation of current design principles to match the actual sequence with the design sequence. Even a very small nucleotide change in the whole genome may impact the phenotype.

Genome design is the basis of synthetic biology. It is crucial to ensure that the novel sequence can support the expected functions and achieve efficient and scalable assembly. The synthetic genome has good application potential in basic research, energy, medicine, environment, and many other fields because of its remarkable improvement in genetic stability and operational flexibility.

Figure 1. Timeline of synthetic genomics milestones from the 1900s to 2017. (Wang L, et al., 2018)

How we can help your genome design

• Our team has the ability to integrate multiple technologies, including characterized genetic parts, synthetic genetic circuits, computer-aided design, gene synthesis and assembly, and genome editing.
• We have a comprehensive toolbox for genome design to fully meet our customers’ requirements.
• We are committed to assisting our customers with designing and optimizing their synthetic biology projects.

Our services include but not limited to the following:

• Code optimization—To help solve the issues related to codon bias.
• DNA design—Fast design of synthetic DNA segments.
• RNA design—Design different types of RNA for specific purposes.
• Chromosome rearrangements by design—Site-specific recombination to engineer chromosome rearrangements.
• Design of reduced and chimeric genomes—To increase genomic stability and improve performance.
• Synthetic genome recoding—To help generate designed organisms with altered phenotypes.

CD Biosynsis offer a variety of cutting-edge techniques to tailor genome design services for individual customer specifications according to criteria that can guide the design of useful biological chassis. We have an experienced scientific team of biologists, bioinformatics, and chemists to help execute innovative designs for unique applications.

We are also available for on-demand customer assistance via email or phone to help you with any problems or concerns you may have. If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

1. Wang L, et al. Synthetic genomics: from DNA synthesis to genome design. Angewandte Chemie International Edition, 2018, 57(7): 1748-1756.
2. Lee B R, et al. Emerging tools for synthetic genome design. Molecules and cells, 2013, 35(5): 359-370.

Please note that all services are for research use only. Not intended for any clinical use.