Genome Editing Service

CD Biosynsis provides powerful genome editing services for synthetic biology researchers around the world to facilitate their cutting-edge research. Our powerful tools can help bring diverse synthetic applications and creative ideas to fruition.

Introduction to Genome Editing

Synthetic biology remolds the existing organisms to generate new features or create artificial lives. New genes, pathways, modules or even whole genomes need to be designed and synthesized. Therefore, enabling technologies, such as gene synthesis, DNA assembly, and genome editing, play a critical in the development of synthetic biology.

Genome editing is a powerful technology to make changes to specific genomic loci, which requires an in-depth understanding of the complex genetic functions of complete genome sequences. It can be used to precisely manipulate genome sequences to meet the design requirements of new biological systems. A variety of multifunctional engineered nucleases with programmable DNA-binding domains have been developed to further improve our ability to make precise changes in the genomes. Furthermore, the rapid development of genome editing technology may shift to synthetic genomics. However, the specificity, efficiency and safety of genome editing must be improved in the future.

Figure 1. Examples of programmable genome editing tools. (Guha T K, et al., 2017)

Comprehensive Genome Editing Toolbox

Our comprehensive genome editing toolbox can meet the individual needs of our customers.

Featured Technologies

CRISPR/Cas9 System

CRISPR-Cas9 was adapted from the genome editing system that naturally occurred in bacteria. We utilize advanced CRISPR/Cas9 technology to provide professional services covering a part or all of the entire genome editing workflow for our customers. CRISPR/Cas9-mediated knockin and knockout can be performed on a wide variety of cell types and species.

Protein-Based Nuclease System

Our protein-based nuclease systems for genome editing incorporate meganuclease, and TALENs. These techniques can be modified to allow genome editing in a variety of model organisms, such as zebrafish, fruit flies, nematodes, and rats. Our services and successful experience can help you get landmark development.

BASE Editing System

Base editing is a newly developed genome editing approach. By using components from CRISPR systems and other enzymes, point mutations can be directly installed into cellular DNA or RNA without making double-stranded DNA breaks. We provide cytosine base editing and adenine base editing in DNA and RNA to help our customers achieve more precise editing.

High-Throughput Gene Editing

Conventional gene editing has the limitation that only one or several genes can be operated in a reaction, thus it is far from meeting the requirements of editing a large number of different genes. We can provide high-throughput genome editing services to enable large-scale genome editing and support the needs of varied research programs.

Competitive Advantages

• Professional in genetic, biochemical, cytological, and physiological analysis.
• Diverse genome editing toolbox.
• Powerful one-stop services for genome editing.
• Successful cases of gene editing in different species.

CD Biosynsis offers a variety of cutting-edge techniques to customize genome editing services for individual customer specifications. If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

1. Guha T K, et al. Programmable genome editing tools and their regulation for efficient genome engineering. Computational and structural biotechnology journal, 2017, 15: 146-160.
2. Lee B R, et al. Emerging tools for synthetic genome design. Molecules and cells, 2013, 35(5): 359-370.

Please note that all services are for research use only. Not intended for any clinical use.