HIF-PH Inhibitors

HIF-PH inhibitors are powerful tools in the field of biotechnology that have the ability to modulate hypoxia signaling pathways Hypoxia-inducible factor (HIF) is a transcription factor that plays a key role in cellular responses to low oxygen levels HIF-PH inhibitors work by inhibiting the activity of prolyl hydroxylase an enzyme that regulates the degradation of HIF By blocking the degradation of HIF these inhibitors stabilize the protein leading to the activation of downstream genes involved in angiogenesis and metabolism These inhibitors have gained significant attention in the development of therapeutic strategies for a range of conditions including anemia kidney disease and cancer

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Products Application Supporting Data Resources Related Products

Products

Catalog Number	Chemical Name	CAS #	Price
EI-0747	DMOG	89464-63-1	Online Inquiry
EI-0977	FG-4592	808118-40-3	Online Inquiry
EI-1220	IOX2	931398-72-0	Online Inquiry
EI-1221	IOX3 (FG-2216)	223387-75-5	Online Inquiry
EI-1258	JNJ-42041935	1193383-09-3	Online Inquiry

Application

HIF-PH Inhibitors have a wide range of applications in both research and medicine In research these inhibitors are utilized to study the hypoxia-inducible factor (HIF) pathway and its role in various biological processes By inhibiting the activity of HIF-PH scientists can better understand how this pathway affects gene expression cell metabolism and adaptation to low oxygen conditions

In medicine HIF-PH inhibitors hold promise as a potential treatment for conditions related to insufficient oxygen supply such as anemia and ischemic diseases By blocking HIF-PH these inhibitors stabilize HIF leading to increased production of erythropoietin a hormone that stimulates the production of red blood cells This can be beneficial for patients with chronic kidney disease or those undergoing chemotherapy-induced anemia

Additionally HIF-PH inhibitors are being investigated as a therapy for cancer By inhibiting HIF-PH these inhibitors can disrupt tumor angiogenesis and promote the immune response against cancer cells This approach shows potential for enhancing the efficacy of existing cancer treatments and overcoming resistance to therapy

Overall HIF-PH inhibitors offer exciting possibilities for both research and therapeutic applications with the potential to improve our understanding of biological processes and provide new avenues for treating various diseases

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Please note that all services are for research use only. Not intended for any clinical use.

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