Strain Hight-throughput screening

Our high-throughput screening services are dedicated to assisting researchers and organizations in achieving their scientific goals efficiently and effectively, leveraging state-of-the-art technology and expertise to accelerate progress in diverse fields of study.

Introduction to High-throughput Screening (HTS)

High-throughput screening, commonly referred to as HTS, is a cutting-edge technique at the forefront of synthetic biology research. HTS is an automated and rapid method for testing a large number of biological or chemical entities in parallel, enabling scientists to efficiently identify novel compounds, enzymes, or genetic constructs with desired properties. This high-capacity screening approach has revolutionized the field of synthetic biology by accelerating the development of new drugs, biofuels, enzymes, and more.

Fig 1. Assay design for high-throughput screening. (Inglese J, et al., 2007)

HTS has its roots in pharmaceutical research, where it was initially employed to identify potential drug candidates from vast compound libraries. Over time, this technology found applications in diverse fields, including synthetic biology. The current trend in HTS research focuses on enhancing throughput, precision, and data analysis methods. In synthetic biology, HTS is increasingly being used to optimize metabolic pathways, discover new biomolecules, and engineer organisms for specific applications.

Our Technologies

Projects We Serve

Our High-throughput screening services cater to various projects, including but not limited to:

• Drug Discovery. Identifying potential drug candidates efficiently.
• Metabolic Engineering. Optimizing pathways for biofuel production or chemical synthesis.
• Enzyme Engineering. Discovering and engineering enzymes for industrial applications.
• Functional Genomics. Screening genetic libraries to uncover gene function.
• Protein-Protein Interaction Studies. Investigating protein interactions for therapeutic targeting.

Workflow of High-Throughput Screening

• Sample Preparation. Compounds, genetic constructs, or biomolecules are arrayed in microplates.
• Assay Execution. Automated systems add reagents and perform assays in parallel.
• Data Collection. Instruments record measurements, such as fluorescence, absorbance, or luminescence.
• Data Analysis. Complex datasets are processed to identify hits and quantify activity.
• Hit Confirmation. Selected hits undergo further validation and characterization.

Competitive Advantages

CD Biosynsis specializes in providing exceptional services in the field of synthetic biology. By choosing our service platform, you have access to our expertise, advanced technologies, and personalized support to take your research to new heights. Contact us to know more details about our services.

Reference

1. Inglese, J.; et al. High-throughput screening assays for the identification of chemical probes. Nature chemical biology. 2007, 3(8), 466-479.

Please note that all services are for research use only. Not intended for any clinical use.