Cas9 Expressing Human lung cancer cells

NCI-H292-CAS9 is a genetically engineered lung epithelial cell line derived from the NCI-H292 non-small cell lung cancer (NSCLC) model featuring the Cas9 endonuclease system for precise genome editing This product empowers researchers by providing a robust platform for studying gene function pathogenesis of cancer and therapeutic responses in a controlled replicable environment The integration of Cas9 allows for targeted modifications to the genome facilitating the study of gene knockouts and the introduction of specific mutations which are critical in elucidating the molecular pathways involved in carcinogenesis and drug resistance

The key mechanism through which NCI-H292-CAS9 operates is the guide RNA (gRNA)-driven targeting of specific DNA sequences enabling site-specific double-strand breaks that are subsequently repaired via cellular mechanisms This not only supports the development of gene-edited cell lines but also serves as a vital tool for examining the effects of genetic alterations on cellular behavior drug efficacy and biomarker discovery In the context of research and clinical applications this product is instrumental for oncology studies including the screening of potential therapeutic agents and the exploration of personalized treatment strategies tailored to molecular profiles unique to NSCLC patients

What sets NCI-H292-CAS9 apart from traditional models is its seamless integration of the Cas9 system into a well-characterized NSCLC background reducing the variability often associated with primary cells and establishing a reliable system for high-throughput screening and mechanistic studies This cell line is invaluable for researchers aiming to advance their work in cancer biology therapeutic development and genomics enabling them to generate data that are both relevant and reproducible

Utilizing NCI-H292-CAS9 provides researchers and clinicians with a cutting-edge tool that aligns with the evolving landscape of precision medicine By offering a versatile platform that promotes innovative research avenues our company showcases its commitment to advancing scientific discovery in oncology and beyond through high-quality and reliable biological products