Mammalian Cell Engineering

CD Biosynsis provides comprehensive mammalian cell engineering services to facilitate the cutting-edge research of synthetic biology researchers around the world.

Introduction to Mammalian Cell Engineering

The original goal of synthetic biology is to develop biological systems for a wide range of applications, ranging from drug discovery and medical applications to industrial, agriculture, and environmental applications. Engineering principles have been applied to synthetic biology to reprogram living cells for novel and improved functions. Mammalian cell engineering is a powerful tool in synthetic biology to reassemble biological components from different organisms into user-defined genetic networks, which can restore, improve, or add essential functions to cells.

With the rapid improvement in the culture and engineering of mammalian cell systems, its importance has been recognized. Taking the expression of recombinant protein as an example, the increase in quantity, quality, and complexity of recombinant proteins largely depends on the ability to engineer mammalian cells. The emerging new synthetic approaches together with a better understanding of cell systems obtained through omics approaches contribute to more flexible and faster mammalian cell engineering.

Figure 1. Biomedical applications of engineered mammalian cells. (Xie M, et al., 2016)

Toolbox for Mammalian Cell Engineering

CD Biosynsis has a powerful synthetic biology toolbox for mammalian cell engineering to help our customers complete application-oriented cell engineering.

Service Offering

CD Biosynsis provides our customers with comprehensive and high-quality mammalian cell engineering services using our powerful toolbox to fully meet their requirements. Our services include but not limited to the following:

Genetic Engineering

Genetic engineering is a powerful tool for engineering complex functions of mammalian cells by manipulating endogenous gene networks. CD Biosynsis provides a comprehensive portfolio of genetic engineering services, including but not limited to genome editing, genome reprogramming, and genetic circuit engineering.

Engineering Cell-to-Cell Communication

Cell-to-cell communication is important for the regulation of various natural biological processes. Mammalian synthetic biology makes it possible to rationally engineer cell-to-cell communication. CD Biosynsis provides mammalian cell engineering services, including engineering by diffusible factors, engineering direct cell-contact-based communication, and engineering to control cross-kingdom communication, to help achieve the control of cell-to-cell communication for therapeutic and other purposes.

CD Biosynsis has developed a comprehensive portfolio of mammalian cell engineering services. We are fully committed to providing our customers with tailored solutions to help them overcome the challenges in synthetic biology and bring diverse creative ideas to fruition.

If you are interested in our services, please contact us for more details.

References

1. Xie M, et al. Synthetic biology—Application-oriented cell engineering. Current opinion in biotechnology, 2016, 40: 139-148.
2. Lanza A M, et al. Emerging synthetic biology tools for engineering mammalian cell systems and expediting cell line development. Current Opinion in Chemical Engineering, 2012, 1(4): 403-410.

Please note that all services are for research use only. Not intended for any clinical use.