Mammalian Synthetic Biology

CD Biosynsis offers customized solutions for mammalian synthetic biology to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to Mammalian Synthetic Biology

Synthetic biology is an emerging, highly interdisciplinary research field with early pioneering research focusing on the standardization of network components for applications in prokaryotic cells. More recent applications have emerged in yeast and mammalian cell lines. Synthetic biology is enabling the cellular and molecular biology study in mammalian cells by advancing the design of genetic devices. Although the field of mammalian synthetic biology initially mimicked and lagged behind early bacterial work, it is now rapidly evolving due to major developments in mammalian genomes manipulation and large DNA circuits cloning methods. Continued improvements in DNA sequencing and synthesis capabilities and the development of novel research tools have led to a rapidly increasing understanding of gene function and regulation at the genome-wide level and have enabled precise control of complex cellular behaviors with unprecedented spatial and temporal resolution. These have been critical in extending synthetic biology techniques from prokaryotic and lower eukaryotic hosts to mammalian systems.

Mammalian cell gene networks are highly complex because they involve regulation at the transcriptional, translational, and posttranslational levels. Consequently, a precise and scalable set of tools is required for mammalian synthetic biology to characterize and control gene expression and function as well as to adapt to the complex hierarchical regulation that governs cellular phenotypes. The development of genome engineering tools has allowed the interrogation and control of gene function and network dynamics. In particular, the CRISPR/Cas9 system has served as the basis for developing tools for programmable and site-specific control of chromatin and transcriptional states. This precise control has enabled the construction of multilayered genetic circuits in mammalian cells. The programming of new functions into mammalian cells has enormous application in research and medicine.

Figure 1. Tools used in mammalian synthetic biology. (Lienert F, et al., 2014)

Applications

Our Solutions

CD Biosynsis offers integrated solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their mammalian synthetic biology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Lienert F, et al. Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nature reviews Molecular cell biology, 2014, 15(2): 95-107.
2. Black J B, et al. Mammalian synthetic biology: engineering biological systems. Annual Review of Biomedical Engineering, 2017, 19: 249-277.

Please note that all services are for research use only. Not intended for any clinical use.