Metabolic Engineering of Microorganisms

CD Biosynsis provides comprehensive services for the metabolic engineering of microorganisms to facilitate the cutting-edge research of synthetic biology researchers around the world.

Introduction to Metabolic Engineering of Microorganisms

Microorganisms have been used in biotechnology processes for thousands of years. Metabolic engineering is the optimization of intracellular genetic and regulatory processes to increase the production of target metabolites. Microbial metabolic engineering has a broad application prospect in industry, medicine, and the environment. Metabolic engineering can ensure the optimal utilization of metabolic pathways by microbial cell factories. In recent years, the emergence of synthetic biology has provided new tools to construct synthetic consortia and program their behaviors. Synthetic biology greatly expands the functions that can be performed by microbial communities.

The focus of synthetic biology is increasingly expanding from single organisms to multiple species within dynamic communities. The unique features of microbial consortia make them an attractive platform for synthetic biology. Recent advances in synthetic biology make it possible to perform metabolic engineering at the whole-cell level, thus enabling the optimal design of microorganisms for a wide range of applications, such as the bioproduction of biofuels, biomaterials and medicines from inexpensive carbon sources.

Figure 1. Engineering Behaviors of Synthetic Microbial Consortia. (McCarty N S & Ledesma-Amaro R., 2019)

Key Applications of Metabolic Engineering of Microorganisms

• Bioproduction of protein complexes
• Production of natural and non-natural chemicals
• Bioproduction of medicines
• Production of nutraceuticals
• Biofuels production
• Functionalized biomaterials
• Biosensing

Service Offering

CD Biosynsis provides a portfolio of synthetic biology tools for the metabolic engineering of microorganisms. Our services include but not limited to the following:

Microbial Consortia Engineering

Synthetic microbial consortia can contain a diverse range of microbial species. Microbial consortia have become a new frontier of synthetic biology because they can perform more complicated tasks and endure more changeable environments than monocultures. CD Biosynsis provides different microbial consortia engineering strategies for different applications.

Microbial Cell Factory Engineering

Microbial cells can be considered as a production facility for bioengineering. The optimization of microbial cell factories largely depends on metabolic engineering. The introduction of new pathways in chassis strains is the core of microbial cell factory development by synthetic biology. CD Biosynsis provides professional and complete services of design and development of microbial cell factories for wide applications in chemical, pharmaceutical, food and biofuel industries.

CD Biosynsis is fully committed to providing our customers with tailored one-stop solutions to help them overcome the challenges in synthetic biology. Our scientists have the ability to bring diverse creative ideas to fruition. If you are interested in our services, please contact us for more details.

References

1. McCarty N S & Ledesma-Amaro R. Synthetic biology tools to engineer microbial communities for biotechnology. Trends in biotechnology, 2019, 37(2): 181-197.
2. Lee S K, et al. Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels. Current opinion in biotechnology, 2008, 19(6): 556-563.

Please note that all services are for research use only. Not intended for any clinical use.