Pharmaceuticals and Therapeutics

CD Biosynsis provides high-quality products as well as flexible services and solutions to support and facilitate the applications of synthetic biology in pharmaceuticals and therapeutics. We offer our expertise to help our customers solve any problems encountered in the project to achieve various research objectives and diversified applications.

Applications of Synthetic Biology in Pharmaceuticals and Therapeutics

Small-molecule drugs are often derived from natural products. However, the difficulties of natural product synthesis have often discouraged the pharmaceutical industry from this rich source of drugs. Recent advances in transformation through genetic manipulation of biosynthetic units in microorganisms have opened up the possibility for the in-depth exploration of the large chemical space of natural product derivatives. Synthetic biology can take advantage of the surprising level of built-in modularity shown by many natural biosynthetic pathways at many levels. Synthetic biology is an emerging discipline that is slowly reorienting the field of pharmaceuticals. Synthetic biology opens a new era of pharmaceuticals using biotechnology such as microbial engineering. The recent avalanche of microbial genome and metagenome sequences has further inspired the synthetic biology of pharmaceuticals. Synthetic biology is now considered a potential tool to massively mine the rich source of drug candidates.

The key aim of synthetic biology is to create functional devices, systems, and organisms with desired functions on the basis of standardized building blocks. Nowadays, Synthetic biology has brought innovative strategies to address various emerging biomedical challenges, such as antibiotic resistance and cancer therapy. Engineered cells capable of integrating multiple inputs or desired proteins produced to target diseased or foreign cells are revolutionizing the way diseases are treated. Engineered biological systems have been employed in different aspects of pharmaceuticals and therapeutics, from drug discovery to personalized medicine. Among the vast number of areas benefiting from synthetic biology, medicine is rapidly pioneering the adoption of the novel tools and strategies developed by this discipline.

Current uses of synthetic biology for pharmaceuticals and therapeutics

• Disease mechanism investigation
• Providing a framework for generating disease models and discovering new drug targets.
• Synthetic cells used as cell-based screening platforms for both target-based and phenotypic-based approaches.
• Engineered genetic circuits used to decipher disease mechanisms or drug mechanism of actions and to study cell-cell communication within bacteria consortia.
• Disease prevention
• Vector control.
• Vaccine development.
• Diagnostics
• Providing novel diagnostic tools with the advantages of real-time, dynamic, sensitive, highly-specific, and non-invasive.
• Monitoring of pharmaceuticals or therapeutics.
• Drug development
• Drug discovery, including those containing non-natural amino acids, novel secondary metabolites, new antibiotics or synthetic DNA vaccines.
• Drug Delivery and nanomedicine.
• Providing novel strategies for the treatment of cancer, immune diseases, infectious diseases, and metabolic disorders.
• Developing alternative therapies, such as gene therapy, protein-based therapies, and CAR-T cell therapy.
• Precision medicine and personalized medicine.
• Pharmaceutical production
• Bioproduction of pharmaceuticals, such as antibiotics and vitamins.
• Providing new and more efficient production platforms.
• Enabling economic production of therapeutics.

What We Provide

CD Biosynsis is committed to developing products and establishing integrated technology platforms that cover a wide range of steps in the synthetic biology workflow. We are adept at tailoring services and solutions to the customer's needs and circumstances. As all of our products and services are based on reliable technologies and optimized protocols to meet high standards, we are confident in the validity and reproducibility of the results we deliver to our customers. Fill out online inquiry form to log your request.

Quote & Ordering

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Breitling R & Takano E. Synthetic biology advances for pharmaceutical production. Current Opinion in Biotechnology, 2015, 35: 46-51.
2. Abil Z, et al. Synthetic biology for therapeutic applications. Molecular pharmaceutics, 2015, 12(2): 322-331.

Please note that all services are for research use only. Not intended for any clinical use.