Plant Metabolic Engineering

CD Biosynsis provides comprehensive services for plant metabolic engineering to facilitate the cutting-edge research of synthetic biology researchers around the world.

Introduction to Plant Metabolic Engineering

Metabolic engineering is different from simple genetic engineering. In metabolic engineering, the metabolic and cellular systems are considered an entirety, thus allowing manipulation with the efficiency of the entire biological process in mind. Plants are the natural source of numerous chemicals synthesized through a complex network of biosynthetic pathways. Plant metabolic engineering involves the modification of endogenous pathways to redirect enzymatic reactions to improve or retard the production of existing compounds, produce novel compounds, or mediate the degradation of certain substances.

The combination of genetic technologies, engineering principles, and computational tools has enabled synthetic biology to create new life forms and functions. Applications of synthetic biology begin with microorganisms and extend to more complicated systems such as plants. A decisive aspect of synthetic biology and plant metabolic engineering is the design-build-test-learn cycle. Iterative rounds of testing modifications are used to refine hypotheses and develop the best solutions. Significant advances have been made in the engineering of plant metabolism, with a wide range of applications. All the technical improvements will facilitate the rapid development of a wide range of biological products to meet the world's needs for sustainable solutions.

Figure 1. Schematic representation of the differences and convergence between synthetic biology and metabolic engineering. (Pouvreau B, et al., 2018)

Key Applications of Plant Metabolic Engineering

• Bioproduction of plant-based natural products
• Production of pharmaceuticals and nutraceuticals
• Biofuel Production
• Agricultural applications

Service Offering

CD Biosynsis provides a portfolio of synthetic biology tools for plant metabolic engineering. Our services include but not limited to the following:

Plant Chassis Selection

The plant chassis has the natural advantages of fine division and synergy of different organs, making it possible to achieve artificial design of complex functions. CD Biosynsis has extensive experience to help customers select the right plant chassis according to specific needs.

Construction of Plant Multigene Transformation Vectors

In order to ensure the metabolic flux of complex metabolic pathways in plants is not restricted, it usually requires the simultaneous expression of multiple genes or even entire genes within a pathway. CD Biosynsis provides different strategies for the construction of plant multigene transformation vectors.

Metabolic Engineering of Plant Secondary Metabolites

Plant secondary metabolites have much more specific functions than primary metabolites. They are also an important source of fine chemicals, such as drugs and dyes. CD Biosynsis provides powerful strategies for metabolic engineering of plant secondary metabolites to improve access to these valuable molecules.

Management and Modulation of Metabolic Flux

Altering the steps or factors affecting the metabolic pathway can increase the metabolic flux of desired metabolites. CD BioSicences provides customized services for the management and modulation of metabolic flux to meet the specific needs of redirecting flux or diverting whole pathway flux.

CD Biosynsis is fully committed to providing our customers with tailored one-stop solutions to help them overcome the challenges in synthetic biology. Our scientists have the ability to bring diverse creative ideas to fruition. If you are interested in our services, please contact us for more details.

References

1. Pouvreau B, et al. From plant metabolic engineering to plant synthetic biology: the evolution of the design/build/test/learn cycle. Plant Science, 2018, 273: 3-12.
2. Sangwan N S, et al. Plant metabolic engineering. Omics Technologies and Bio-Engineering. Academic Press, 2018: 143-175.

Please note that all services are for research use only. Not intended for any clinical use.