PMS1 Knockout cell line （U-2 OS）

PMS1 Knockout cell line (U-2 OS) is primarily utilized in cancer research and genetic studies focusing on DNA mismatch repair mechanisms This engineered cell line provides an ideal platform for investigating the functional consequences of PMS1 gene deletion in relation to microsatellite instability and tumorigenesis Specific use cases include assessing the effects of PMS1 deficiency on sensitivity to chemotherapy agents enabling researchers to elucidate the role of mismatch repair in drug resistance

In experimental workflows researchers can implement the PMS1 Knockout cell line by conducting proliferation assays apoptosis assays or using CRISPR technology for gene editing studies The practical benefits of utilizing this cell line include the ability to model human cancer pathophysiology more accurately leading to improved understanding of disease mechanisms and potential therapeutic targets Moreover this knockout model excels in combination with techniques such as RNA sequencing and protein interaction studies facilitating comprehensive data analysis in the field of oncology