Preparation of Nucleic Acid-based Materials by Synthetic Biology

CD Biosynsis leverages synthetic biology approaches and our expertise in material sciences to bring new ideas to the production of nucleic acid-based materials for diverse applications such as biomedicine and biosensing. We have assembled a multidisciplinary scientific team to harness the power of synthetic biology to promote the development of material sciences.

Background

Nucleic acids as essential biomacromolecules have become key players in material sciences due to their unique and attractive properties such as programmability, biocompatibility and biodegradability. Because the extraordinary precise molecular recognition capability of nucleic acids, the combination of DNA and RNA has the potential to produce infinite two- and three-dimensional nanostructures whose size, shape and spatial functionalization can be precisely controlled. Although nucleic acids seem to be the ideal nanomaterials, the preparation of nucleic acid-based materials is far from easy. Synthetic biology that uses the Design-Build-Test-Learn (DBTL) cycle to precisely control biological networks offers unique opportunities to the preparation of nucleic acid-based materials and has great potential to create new materials.

What We Can Do

CD Biosynsis have built a powerful toolbox for synthetic biology, covering advanced technologies such as nucleic acid synthesis, modular DNA assembly, nucleic acid nanotechnology, computer-aided design, and genetic circuit engineering. We are constantly exploring the potential of synthetic biology in the preparation of nucleic acid-based materials.

• We offer our in-depth understanding of DNA/RNA nanostructures, particularly DNA/RNA tiles, DNA origami, DNA tetrahedron, DNA polyhedrons, nucleic acid dendrimers, and hybrid DNA-RNA nanostructures.
• We use our synthetic biology capabilities to help our customers overcome challenges in the preparation of nucleic acid-based materials.
• Synthesis and assembly of genetically encode nucleic acid structures in living cells.
• Mass production of DNA origami using cell-based approaches.
• Programmed self-assembly of nucleic acids.
• Large-scale production of nucleic acid nanostructures.

Applications of Nucleic Acid-based Materials

Much progress has been made in using nucleic acid-based materials for diverse applications. CD Biosynsis' ability to develop synthetic biology strategies and tools allows us to help our customers obtain nucleic acid-based materials that meet their intended applications.

Biomedical applications	Chemotherapy (e.g., DNA origami, DNA dendrimers, and DNA tetrahedron) Gene therapy (e.g., DNA polyhedrons, DNA nanovehicles, and RNA nanoparticles) Immunotherapy (e.g., DNA nanoclews) Drug delivery (e.g., wireframe DNA cages) Diagnosis (e.g., cancer diagnosis)
Biosensing	Small molecules sensing Nucleic acids biosensing Protein biosensing Tumor cell detection Virus detection
Bioimaging	Imaging of biomolecules In vivo imaging (e.g., brain tumor imaging)

Want to Learn More?

CD Biosynsis is committed to helping our customers meet the growing and evolving demand for nucleic acid-based materials using the in-depth intersection of synthetic biology and materials science. Our scientists are well positioned to provide full support for their innovative ideas. If you are interested in our services or have any questions, please do not hesitate to contact us.

References

1. Burgos-Morales O, et al. Synthetic biology as driver for the biologization of materials sciences. Materials Today Bio, 2021, 11: 100115.
2. Li H, et al. Nucleic acid-based nanoengineering: novel structures for biomedical applications. Interface focus, 2011, 1(5): 702-724.

Please note that all services are for research use only. Not intended for any clinical use.