Protein Structure Determination

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CD Biosynsis provides comprehensive protein characterization services for synthetic biology researchers around the world to facilitate their cutting-edge research.

Introduction to Protein Structure Determination

The functions of biological macromolecules mainly depend on their three-dimensional structure, movements, and interactions. Protein structure analysis can provide information on protein classification, protein function, protein interactions, posttranslational modifications, and many other aspects. It fundamentally clarifies the molecular mechanism, and is also an important way to study protein function. At present, there are three main methods to determine the 3D structure of proteins, including X-ray crystallography, nuclear magnetic resonance technology (NMR), and 3D reconstruction technology of cryo-electron microscopy. One of the central goals of synthetic structural biology is to create proteins with novel structures. Therefore, protein structure determination plays a critical role in synthetic biology.

Comparison of Methods for Determining Protein Structure

Protein Structure Determination

Service Offering

Equipped with advanced NMR, X-ray crystallography, and cryo-EM platform, CD Biosynsis provides our customers with professional protein structure determination services.

Nuclear Magnetic Resonance (NMR)

CD Biosynsis provides expertise in NMR spectroscopy to help accelerate research on high-resolution protein structure determination, ligand binding determination, and fragment screening in solution.

X-Ray Crystallography

CD Biosynsis provides professional services for high-quality crystal production, X-ray diffraction data collection, and structure determination using X-ray crystallography as a powerful tool to meet the specific needs of our customers.

Cryo-Electron Microscopy (Cryo-EM)

CD Biosynsis has the all-in-one cryo-EM process from protein production, sample preparation, imaging data processing to final model construction, which can handle large molecules and their complexes with small ligands, proteins, and nucleic acids.

Ordering Process

Ordering Process of Protein Structure Determination Services – CD Biosynsis

CD Biosynsis is confident in providing high-quality protein structure determination services. If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

Grünberg R & Serrano L. Strategies for protein synthetic biology. Nucleic acids research, 2010, 38(8): 2663-2675.
Henrich E, et al. Synthetic biology-based solution NMR studies on membrane proteins in lipid environments. Methods in Enzymology. Academic Press, 2019, 614: 143-185.

Please note that all services are for research use only. Not intended for any clinical use.

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