Protein Synthetic Biology

CD Biosynsis offers customized protein synthetic biology solutions to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to Protein Synthetic Biology

The accuracy of protein synthesis and the stability of cellular proteomes play an essential role in cell viability. Among the various biological building blocks, proteins are the most versatile macromolecules. Protein engineering has already been a well-established field with a wide range of applications in industry and biomedicine. However, the versatility, dynamics, and interactions of proteins also complicate system engineering. The design of more sophisticated protein systems appears somewhat delayed compared to the engineering of gene regulatory networks. Because of this, synthetic biologists have begun tinkering with the information flow through integrated protein switches. Most successful experimental strategies have focused on modular interactions between protein domains and peptide motifs. A solid mechanistic biochemical understanding of the synthetic process is required to engineering the protein synthesis machinery. Expanding the genetic code for the synthesis of proteins containing non-canonical amino acids (ncAAs) is becoming a rapidly growing area in synthetic biology.

Researchers have long been studying the structure, function, interactions, and chemistry of proteins, and have gained a growing body of experience in protein design and engineering. Recent studies have jumped from the manipulation of individual proteins to the design of larger assemblies or protein networks/systems that combine different functions. Known protein sequences and structures, modulable molecular dynamics and reactions, and measurable rate and equilibrium constants all contribute to protein circuit engineering in vitro. Protein circuits could have a huge impact on the way we understand life. Synthetic multicomponent protein systems may also turn out to be valuable research tools.

Figure 1. Protein synthetic biologists assemble artificial fusion proteins from reusable segments—or parts. (Grünberg R & Serrano L., 2010)

Applications

Our Solutions

CD Biosynsis offers integrated protein synthetic biology solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their synthetic biology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Grünberg R & Serrano L. Strategies for protein synthetic biology. Nucleic acids research, 2010, 38(8): 2663-2675.
2. O'donoghue P, et al. Upgrading protein synthesis for synthetic biology. Nature chemical biology, 2013, 9(10): 594-598.

Please note that all services are for research use only. Not intended for any clinical use.