Proteomic Analysis

CD Biosynsis provides specialized proteomic analysis for the test phase of synthetic biology to help researchers around the world facilitate their cutting-edge research. Equipment with an advanced technology platform and powerful synthetic biology tools, we have the ability to help bring diverse synthetic biology applications and creative ideas to fruition.

Introduction to Proteomic Analysis

The synthesis of complex biological functions using basic molecular parts is one of the main objectives of synthetic biology. This bottom-up approach has been used to purposefully manipulate cellular systems for specific applications. Synthetic biology ostensibly focuses on the manipulation of gene regulatory networks; however, a series of recent studies have pointed that proteins are an optimal substrate for the engineering of biological systems and the most versatile among the various biological building blocks. Nevertheless, the versatility, dynamics and interactions, and other complex characteristics of proteins, also hinder systems engineering. This remains to be tamed by a robust engineering framework.

Synthetic biologists have begun tinkering with the information flow through integrated protein switches. Proteomic analysis, which identifies and quantifies the complete proteins of a biological system at a specific time point, can help synthetic biologists obtain well-characterized biological parts to facilitate system design. Frameworks based on natural modularity and specific interactions may allow the assembly of synthetic networks from reusable protein (and non-protein) devices. Protein interaction devices that integrate synthetic RNA and gene networks with non-natural chemistry and metabolic engineering will take center stage in future systems.

Figure 1. Introduction of systems and synthetic biology to construct microbial cell factories for the improved production of organic acids. (Guan N & Liu L., 2020)

Featured Services

CD Biosynsis offers a complete set of tools for proteomic analysis and synthetic biology to help our customers overcome the challenges in synthetic biology. Browse our featured services below or use our online inquiry form to get more information.

Targeted Proteomics

Targeted proteomics, an emerging area of proteomics used for protein and peptide quantification, has the advantages of high sensitivity, quantitative accuracy, reproducibility, and multiplexing capabilities. CD Biosynsis offers specialized targeted proteomics services to provide our customers with the key functional insights they need to move forwards.

Quantitative Proteomics

Quantitative proteomics is a powerful approach used to quantify global changes in protein abundance and providing information about the physiological differences between samples. The scientific team at CD Biosynsis is dedicated to helpinging our customers determine the best proteomics approaches for their synthetic biology projects and to driving their projects forward.

Functional Proteomics

Functional proteomics, also known as differential proteomics, can elucidate the biological function of proteins at the proteome-wide level and define cellular mechanisms at the molecular level. CD Biosynsis provides functional proteomics to help our customers transform their scientific hunches into new discoveries.

Mass Spectrometry (MS)-Based Proteomics

Mass spectrometry is the most commonly used technique for proteome analysis. Mass spectrometry (MS)-based proteomics has become a broadly effective approach to identify, characterize, and quantify proteins. CD Biosynsis has established advanced mass spectrometry platforms to help elucidate the limitations in synthetic biology.

Proteome Informatics

Proteome informatics is a set of bioinformatic methods for collecting and analyzing complex datasets. Biosynsi has the expertise in proteome informatics to analyze the results of proteome experiments from cells, tissues, organs, or organisms.

CD Biosynsis offers a variety of cutting-edge techniques to customize services for individual customer specifications. Our experienced scientific team of biologists, bioinformatics, and chemists is dedicated to helpinging our customers solve any problems encountered in their synthetic biology projects.

If you are interested in our services or have any specific needs, please feel free to contact us for more details.

References

1. Guan N & Liu L. Microbial response to acid stress: mechanisms and applications. Applied microbiology and biotechnology, 2020, 104(1): 51-65.
2. Gallo G, et al. From microbial proteomics to synthetic biology: Amycolatopsis balhimycina case. CHEMICAL ENGINEERING, 2012, 27.

Please note that all services are for research use only. Not intended for any clinical use.