RNA Synthetic Biology

CD Biosynsis offers customized RNA synthetic biology solutions to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to RNA Synthetic Biology

Since the ability to engineer biological systems is directly and closely related to the ability to control gene expression, a central focus and one of the long-term goals of synthetic biology is the development of programmable gene regulatory systems and the construction of large-scale genetic networks that enable the control and manipulation of cell behavior by tweaking natural regulatory mechanisms or “switches” in order to achieve the desired functions. RNA molecules, by virtue of their interactions with other nucleic acids, proteins, and small molecules, play important and diverse regulatory roles in the cell. Inspired by this natural versatility, RNA molecules with new biological functions have been engineered. Regulatory mechanisms involving RNA building blocks, such as mRNAs, microRNAs, and riboswitches, are becoming increasingly prominent. Synthetic biology research is increasingly turning its attention to RNA regulators because of their versatility and the emergence of new and powerful design principles.

In recent years, novel, synthetic RNA components have been developed, primarily for regulating gene expression in bacteria and yeast. Functional RNAs that respond to other nucleic acids, proteins, or small molecules can be used to precisely control gene regulation. This has laid the foundation for scalable and programmable cell behavior. The imperative in this emerging field is to determine how to increase the complexity of engineered RNA systems through computational and directed-evolutionary techniques, as well as to determine how these systems can be broadly extended to mammalian systems. High-throughput RNA structure characterization experiments and new computational tools help to unravel the sequence-structure-function relationship of RNA and accelerate our understanding of RNA folding, function, and design to further engineering these powerful molecules.

Figure 1. Advances in synthetic RNA regulators of gene expression. (Chappell J et al., 2015)

Applications

Our Solutions

CD Biosynsis offers integrated RNA synthetic biology solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their synthetic biology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Isaacs F J, et al. RNA synthetic biology. Nature biotechnology, 2006, 24(5): 545-554.
2. Chappell J et al. A renaissance in RNA synthetic biology: new mechanisms, applications and tools for the future. Current opinion in chemical biology, 2015, 28: 47-56.

Please note that all services are for research use only. Not intended for any clinical use.