Strain Domestication Service

Introduction

Microbial strains play a significant role in the production of various industrial compounds, such as biofuels, chemicals, and pharmaceuticals. However, the performance of these strains is often limited by their natural diversity, making it challenging to achieve high production yields and efficiency. To overcome these limitations, researchers have turned to synthetic biology and strain domestication as promising strategies for improving microbial strains.

CD Biosynsis puts much emphasis on strain domestication in synthetic biology and aims to help reseachers make advancements in this field.

Figure 1: The role of RapP in the domestication of strain 168. (Pollak, S., Omer Bendori, S., et al. 2015)

Our Services for Strain Domestication

At CD Biosynsis, we offer a range of services for strain domestication using synthetic biology techniques. Our team of experts is dedicated to improving microbial strains for industrial applications and providing tailored solutions to meet our clients' needs.

Strain Selection and Improvement

We use a combination of traditional and modern methods for strain selection and improvement. Our team of experts conducts a thorough analysis of existing microbial strains to identify those with beneficial traits. We then use synthetic biology techniques such as genome editing and metabolic engineering to improve these strains further.

Design and Optimization of Metabolic Pathways

Our team is specialized in designing and optimizing metabolic pathways for the production of desired compounds. We use a combination of computational modeling and experimental approaches to design and engineer metabolic pathways that are efficient and cost-effective.

Genome Editing and Genetic Modification

We use advanced genome editing techniques such as CRISPR-Cas9 and TALENs to modify the microbial genome and introduce beneficial traits. Our team is proficient in designing and implementing these techniques to achieve precise genetic modifications.

Directed Evolution

Our team uses directed evolution to improve microbial strains by mimicking natural selection in the laboratory. We expose microbial populations to selective pressure and monitor their evolution over time, selecting the most promising strains for further improvement.

Our Advantages

At CD Biosynsis, we pride ourselves on our expertise in synthetic biology and our cutting-edge technologies for phenotypic screening and selection. Our advantages include:

1. Expertise and Experience
2. Cutting-Edge Technology
3. Tailored Solutions
4. Quality Control

At CD Biosynsis, we offer a range of services for strain domestication, including strain selection and improvement, metabolic pathway design and optimization, genome editing and genetic modification, and directed evolution. Our team of experts has the expertise and experience to provide tailored solutions to meet our clients' specific needs. Contact us today to learn more about our services and how we can help improve your microbial strains for industrial applications.

References

1. Pollak, S., Omer Bendori, S., et al. A complex path for domestication of B. subtilis sociality. Current Genetics. 2015 61, 493–496. https://doi.org/10.1007/s00294-015-0479-9.
2. Steensels J., Snoek T., et al. Improving industrial yeast strains: exploiting natural and artificial diversity. FEMS microbiology reviews. 2014 38(5):947-95. doi: 10.1111/1574-6976.12073.

Please note that all services are for research use only. Not intended for any clinical use.