Strain Engineering for Acetic Acid

CD Biosynsis can help our customers develop synthetic biology tools and strategies to achieve efficient bio-production of acetic acid to meet the world's rising demand for acetic acid and its derivatives. We aim to promote the shift of the acetic acid production towards a sustainable, economical, and environmental-friendly process.

Advantages of Synthetic Biology-Driven Acetic Acid Production

Acetic acid with the molecular formula CH₃COOH is also known as ethanoic acid. It is an important industrial chemical with a wide range of applications. Acetic acid can be produced by chemical synthesis and bacterial fermentation. In current industrial practice, chemical synthesis is still the dominant method. Conventional chemical synthesis routes for acetic acid production are typically multi-step processes that consume large amounts of energy, materials, labor, and capital, and do not ensure clean production. However, biological methods account for only 10 percent of world production and are mainly used for vinegar production. Emerging synthetic biology technologies have the potential to make an important contribution to the development of sustainable feedstocks and novel green production process to meet the growing global demand for acetic acid and to combat global warming.

Figure 1. The combination of systems biology- and synthetic biology-guided metabolic engineering for acid tolerance and productivity. (Gao L, et al., 2020)

What We Provide

Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of acetic acid.

Deliverables

• Acetic acid-producing microorganisms.
• High-quality acetic acid and its derivatives.

How We Can Help

CD Biosynsis has established a synthetic biology platform for acetic acid biosynthesis. By utilizing various advanced tools such as genomics, transcriptomics, proteomics, metabolomics, fluxomics, in silico modeling, and metabolic engineering, we have the ability to develop effective strategies for efficient production of bio-based acetic acid.

Engineering of Acetic Acid Bacteria (AAB) to Improve Acetic Acid Production

We have powerful genetic engineering tools and pathway optimization strategies for the engineering of acetic acid producing pathways such as ethanol oxidation pathway, Wood-Ljungdahl pathway, and the glycine synthase pathway in aerobic and anaerobic bacteria to achieve high productivity and improved acetic acid tolerance. The metabolic engineering approaches available in AAB listed below include overexpression of membrane-bound alcohol dehydrogenase (ADH), membrane-bound aldehyde dehydrogenase (ALDH) or aconitase for pathway optimization, disruption of the GinI/GinR quorum-sensing system, and overexpression of acid tolerance-related genes. If you are interested in other bacteria strains, please fill out the online inquiry form and tell us more about your project.

Production of Acetic Acid from Algae

Our scientists with expertise in algae synthetic biology are working to explore the possibility of producing acetic acid from microalgae such as Chlorella sp. and Tetraselmis suecica. We expect to develop a promising process for acetic acid production using microalgae biomass as feedstock. Our dedicated scientists also aim to develop a sustainable and eco-friendly process for the production of acetic acid from algae.

Applications of Acetic Acid

CD Biosynsis can provide our customers with customized solutions for efficient acetic acid production to support their downstream applications across various industries.

• Used as a flavoring agent, acidulant, edible packing, antimicrobial agent, and mild descaling agent in the food industry.
• Used in the production of vinyl acetate monomer, acetic anhydride, cellulose acetate, acetic esters, chloroacetic acid, and agrochemicals.
• Used in the production of synthetic fibers and fabrics, polymer, plastics, dyes, coatings, rubber, wood glue, varnishes, lubricants, soaps and detergents, and insecticides.
• Used in the manufacture of hormones, antibiotics, vitamins, and other pharmaceuticals.
• Used in the production of cosmetics and personal care products.
• Used as a solvent for paints, resins, and lacquers.

Want to Learn More?

As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

1. Gao L, et al. Metabolic engineering to improve the biomanufacturing efficiency of acetic acid bacteria: advances and prospects. Critical reviews in biotechnology, 2020, 40(4): 522-538.
2. Vidra A & Németh Á. Bio-produced acetic acid: A review. Periodica Polytechnica Chemical Engineering, 2018, 62(3): 245-256.

Please note that all services are for research use only. Not intended for any clinical use.