Strain Engineering for Anthocyanidin

CD Biosynsis provides services to optimize the entire process of anthocyanin biosynthesis based on synthetic biology strategies in order to improve the commercial competitiveness of microbial anthocyanin production.

Background

Anthocyanins are the most abundant and important class of water-soluble pigments in nature and are responsible for the red, purple, or blue color of the leaves, flowers, fruits, and tubers of certain plants. Anthocyanins have a wide variety of functions and have been widely used in the food, cosmetic and pharmaceutical industries. At present, anthocyanins mainly rely on plant extracts, which are difficult to meet their large-scale industrial applications. Therefore, the synthesis of anthocyanins using synthetic biology techniques is an important means to secure anthocyanin production.

Figure 1. The strategies applied in metabolic engineering of E. coli for the biosynthesis of anthocyanins. (Zha J, et al., 2017)

What We Provide

Based on synthetic biology strategies, we are able to optimize the microbial production process of anthocyanins and maximize the potential of the anthocyanin biosynthesis pathway.

Deliverables

• Efficient cell factory for anthocyanidin production.
• Anthocyanidin.

How We Can Help

Development of Microbial Chassis for Anthocyanidin Production

The production of anthocyanins by microbial fermentation is an attractive alternative to the production of anthocyanins from plants. Based on the anthocyanin synthesis pathway, we are able to help our customers design microbial cell factories for anthocyanin production. The following are the microbial chassis that has been used for the production of anthocyanidin. Please contact us directly if you have other chassis of interest for anthocyanidin production.

Biosynthesis of Plant-Specific Anthocyanins

We are able to help our customers construct an artificial gene cluster containing genes from the source of the plant anthocyanin synthesis pathway, enabling the production of plant-specific anthocyanin molecules.

Enzyme Screening for Anthocyanin Production

The construction of microbial cell factories for anthocyanin production requires enzymes of different plant origins. We are able to help our customers to screen enzymes from different species that contribute to anthocyanin production and build the most suitable system.

Applications of Anthocyanidin

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive anthocyanidin production and meet the needs of customers in a variety of industries.

• As a food coloring agent.
• Used to suppress neuroinflammation.
• Used in the treatment of cancer.
• For the treatment of cardiovascular diseases.
• For the treatment of neurodegenerative diseases.
• Used to fight against UV-induced skin damage.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in anthocyanidin production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

1. Zha J, et al. Metabolic engineering of Corynebacterium glutamicum for anthocyanin production. Microb Cell Fact. 2018 Sep 14; 17(1): 143.
2. Zha J, Koffas MAG. Production of anthocyanins in metabolically engineered microorganisms: Current status and perspectives. Synth Syst Biotechnol. 2017 Oct 31; 2(4): 259-266.

Please note that all services are for research use only. Not intended for any clinical use.