Strain Engineering for Artemisinin

CD Biosynsis is able to apply tissue culture, genetic engineering, and metabolic engineering technologies to up-regulate artemisinin production to meet our customers' needs for artemisinin production.

Background

Artemisinin is an effective antimalarial monomer isolated from Artemisia annua. At present, the raw material for artemisinin production basically relies on wild plants and artificially cultivated artemisia. Artemisinin is mainly extracted from Artemisia plants. However, natural wild artemisinin is limited by geographical and seasonal factors to meet the sustainable production of artemisinin. Artificial cultivation of Artemisia annua is time-consuming and labor-intensive, and yield is difficult to guarantee. In addition, the chemical synthesis route of artemisinin is complex, costly, and unsuitable for industrial production. Therefore, the development of biosynthetic pathways for artemisinin is of great value.

Figure 1. Schematic Representation of Artemisinin Biosynthesis by Sequential Metabolic Engineering of Chloroplast and Nuclear Genomes. (Malhotra K, et al., 2016)

What We Provide

Artemisinin is a secondary metabolite of Artemisia annua. The synthesis of secondary metabolites in plants is influenced by several factors. We are able to use synthetic biology strategy to up-regulate artemisinin production in bioreactors.

Deliverables

• Efficient plant cell factory for artemisinin production.
• Artemisinin.

How We Can Help

Construction of Artemisia Isolated Culture System

The synthesis of artemisinin is closely related to the differentiation of Artemisia plant tissues. We can help our customers to optimize the isolated culture conditions and solve the problem of artemisinin production through tissue culture technology.

Optimization of the Metabolic Pathway of Artemisinin

With the development of molecular biology techniques, we are able to regulate the expression of several genes in the metabolic pathway to promote the production of artemisinin in Artemisia annua through genetic engineering methods.

Development of Heterologous Expression System for Artemisinin Production

We are able to establish an agrobacterium-mediated artemisia transformation system to transfer artemisinin synthesis-related genes into plants and achieve artemisinin expression in heterologous plants.

Applications of Artemisinin

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive artemisinin production and meet the needs of customers in a variety of industries.

• It has an anti-malarial effect.
• It has antitumor effects.
• Used in the treatment of cardiovascular diseases.
• Used in the treatment of leukemia.
• It has an antibacterial effect.
• It has an anti-inflammatory effect.
• Used in the treatment of neurological disorders.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in artemisinin production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

Reference

1. Malhotra K, et al. Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells. Mol Plant. 2016 Nov 7; 9(11): 1464-1477.

Please note that all services are for research use only. Not intended for any clinical use.