Strain Engineering for Catechol

Online Inquiry

CD Biosynsis is dedicated to the development of microbial chassis capable of producing catechol from simple carbon sources and offers genetic engineering modification services for engineered strains, aiming to help customers increase the productivity of catechol.

Advantages of Synthetic Biology-Driven Catechol Production

Catechol is a class of phenolic active substances extracted from natural plants such as tea leaves. Catechol and its downstream products have great market potential, therefore, it is important to develop ways to produce catechol on a large scale. The chemical synthesis of catechol possesses several process routes. Among them, research on catechol biosynthesis has focused on the development of enzymes that allow efficient production of catechol under very mild conditions by combining organic chemistry with biotechnology.

Figure 1. Metabolic network related to catechol biosynthesis in E. coli. (Balderas-Hernández VE, et al., 2014)

What We Provide

Based on our synthetic biology design and construction services, we expect to use advanced technology to help our customers develop microbial cell factories capable of efficient catechol.

Genetic Engineering

We are able to use molecular biology and microbiology to introduce genes from different sources into microbial cells to alter the biosynthetic pathway of catechol and help our customers obtain high-quality engineered bacteria.

Metabolic Engineering

We are able to modify and alter the catechol synthesis pathway of the engineered bacteria using multiple gene recombination techniques.

Deliverables

Catechol producing microorganisms.
Catechol.

How We Can Help

Development of Microbial Chassis for Catechol Production

We are working on the development of methods for the synthesis of catechol from renewable resources as a carbon source. The following table shows the microbial chassis that we have successfully developed that can utilize glucose, etc. as a carbon source. Please contact us directly if you have other chassis of interest for arginine production.

Pseudomonas putida

Saccharomyces cerevisiae

Escherichia coli

Development of an Intelligent Synthetic Biology Chassis

Our scientists have been trying to develop intelligent microbial chassis based on their research on microbial cell factories. We expect to help our customers develop a low-cost and reliable platform for catechol synthesis by integrating the catechol biosynthesis pathway and active aromatic transport protein expression to build an autoregulated microbial cell factory. If you are interested in our automated system construction project, please contact us for details.

Genetic Improvement of Metabolically Engineered Strains

We provide genetic modification services targeting the catechol biosynthesis pathway, applying metabolic engineering strategies to modify engineered bacteria to help our customers increase the yield of catechol.

Applications of Catechol

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive catechol production and meet the needs of customers in a variety of industries.

As an important pesticide intermediate.
As a raw material for the synthesis of vanillin synthesis.
As an important pharmaceutical intermediate.
As a photosensitive material.
Used in the rubber industry for the preparation of adhesives.
Used in the manufacture of antioxidants and anti-odorants.
Used in the prevention and treatment of cardiovascular diseases.
Used to prevent cancer.
Used to prevent tooth decay.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in catechol production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

Reference

Balderas-Hernández VE, et al. Catechol biosynthesis from glucose in Escherichia coli anthranilate-overproducer strains by heterologous expression of anthranilate 1,2-dioxygenase from Pseudomonas aeruginosa PAO1. Microb Cell Fact. 2014 Oct 4; 13: 136.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.