Histidine Strain Engineering

CD Biosynsis specializes in providing comprehensive strain engineering services tailored specifically for histidine production. Leveraging cutting-edge biotechnological techniques, we offer solutions that cater to the scientific community's specific needs.

Background

The primary objective of strain engineering for histidine is to manipulate the genetic and metabolic pathways within the host organism to increase histidine production, improve its quality, or modulate its regulation. This process typically involves the selection and modification of key enzymes and regulatory elements involved in the histidine biosynthesis pathway.

Fig 1. Production of l-histidine from glucose by metabolically engineered Escherichia coli. (Wu H, et al., 2020)

By applying advanced biotechnological tools such as CRISPR-Cas9 genome editing and synthetic biology techniques, scientists can precisely alter the genetic makeup of microorganisms, plants, or cell cultures to achieve specific histidine-related goals. This technology has the potential to revolutionize histidine production, making it more efficient, cost-effective, and tailored to diverse research and industrial needs.

Services Offering

As a biotechnology company providing services for scientific purposes, our offerings encompass the following technological solutions:

• Strain Design: Creation of transgenic strains optimized for histidine production. Enhance the biosynthetic pathways involved in histidine production through precise genetic manipulation to ensure maximum yield.
• Metabolic Engineering: Metabolic engineering techniques were used to fine-tune cellular metabolism and shift resources to histidine biosynthesis. This optimization increases histidine productivity.
• Fermentation Process Optimization: Provides services to optimize the fermentation process to ensure ideal conditions for histidine production, such as pH control, temperature regulation, and nutrient supplementation.
• Strain Characterization: Our comprehensive strain characterization services include analyzing the genetic and physiological properties of engineered strains.
• Customized Genetic Tools: We develop tailored genetic tools and vectors to facilitate histidine-related research. These tools enable precise genetic modifications and evaluations.

Areas of Application of Our Services

• Strain Design: Creation of transgenic strains optimized for histidine production. Enhance the biosynthetic pathways involved in histidine production through precise genetic manipulation to ensure maximum yield.
• Metabolic Engineering: Metabolic engineering techniques were used to fine-tune cellular metabolism and shift resources to histidine biosynthesis. This optimization increases histidine productivity.
• Fermentation Process Optimization: Provides services to optimize the fermentation process to ensure ideal conditions for histidine production, such as pH control, temperature regulation, and nutrient supplementation.
• Strain Characterization: Our comprehensive strain characterization services include analyzing the genetic and physiological properties of engineered strains.
• Customized Genetic Tools: We develop tailored genetic tools and vectors to facilitate histidine-related research. These tools enable precise genetic modifications and evaluations.

Our strain engineering services provide a cutting-edge solution for your histidine needs in scientific research. With technical expertise, state-of-the-art techniques, and a commitment to quality, we are your trusted partner in the biosynthesis of histidine. Contact us today to discuss how we can support your research endeavors and elevate your scientific outcomes.

Reference

1. Production of l-histidine from glucose by metabolically engineered Escherichia coli.

Please note that all services are for research use only. Not intended for any clinical use.