Synthetic Biology Chassis Development

CD Biosynsis provides synthetic biology chassis development services to facilitate the cutting-edge research of synthetic biology researchers around the world.

Introduction to Synthetic Biology Chassis

As an interdisciplinary field, synthetic biology introduces engineering principles into life sciences to generate novel, designed biological networks. In addition to a library of well-characterized genetic fragments (BioBricks), another important prerequisite for the rational assembly of biological devices is a robust structural basis, i.e. the chassis. Although a great deal of research has focused on programming, far less has focused on the chassis itself. A very small set of domesticated, laboratory organisms highly adapted to laboratory conditions became legacy synthetic biology chassis. However, these are not the ideal chassis. Synthetic biology capabilities to advance medicine, academia, and industry require new chassis.

Selecting an appropriate chassis to display minimal biological complexity to ensure predictable behaviors is essential for organism engineering to edit genomes, combine traits from different source species, and control genes with synthetic circuits. These synthetic biological chassis can either be constructed in a top-down or a bottom-up strategy. Synthetic biology capabilities have advanced from gene mutations to complex synthetic circuits and synthetic genomes, enabling the development of the next generation of synthetic biology chassis to provide the advanced physiology novel synthetic circuits. This will help move synthetic biology from the laboratory into fieldable technologies.

Figure 1. The next generation of synthetic biology chassis. (Adams B L., 2016)

Service Offering

CD Biosynsis provides synthetic biology chassis development services of different types of chassis to meet the different needs of synthetic biology research. Our services include but not limited to the following:

Minimal Genomes as Chassis

The minimal genome can be used as a chassis for the construction of custom-designed genomes for a wide range of practical and industrial applications. CD Biosynsis has the ability to construct minimal genomes as chassis for synthetic biology to provide desired functions.

Bacterial Chassis

The emergence of bacterial chassis is considered in light of their unique physiological and metabolic properties. Their performance in practical applications is expected to surpass other microbial platforms. CD Biosynsis is capable of developing a panel of bacterial chassis that can thrive under a variety of conditions to expand the current scope of synthetic biology.

Cell-Free Synthetic Biology Chassis

The emergence of cell-free synthetic biology techniques provides the framework for the assembly of multiple cellular processes. CD Biosynsis has an advanced cell-free synthetic biology platform to construct synthetic biology chassis for a wide range of applications.

Other Chassis

CD Biosynsis has been committed to promoting the development of synthetic biology.  Our experienced scientists have experience in successfully building the chassis of other species, such as fungi, phage, algae, plants, and mammals.

CD Biosynsis is fully committed to providing our customers with tailored one-stop solutions to help them overcome the challenges in synthetic biology. Our scientists have the ability to bring diverse creative ideas to fruition. If you are interested in our services, please contact us for more details.

References

1. Adams B L. The next generation of synthetic biology chassis: moving synthetic biology from the laboratory to the field. ACS Synth Biol, 2016, 5(12): 1328-1330.
2. Kim K, et al. Engineering Biology to Construct Microbial Chassis for the Production of Difficult-to-Express Proteins. International Journal of Molecular Sciences, 2020, 21(3): 990.

Please note that all services are for research use only. Not intended for any clinical use.