Synthetic Glycobiology

CD Biosynsis offers customized synthetic glycobiology solutions to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to Synthetic Glycobiology

Every biological cell is covered in a forest-like coating of complex carbohydrates known as the glycocalyx. Protein-carbohydrate interactions play essential roles in cell adhesion and endocytosis. Many viruses, bacteria, parasites, and their toxins also exploit these mechanisms to target and enter cells. Glycans and protein glycosylation are directly involved in virtually all biological processes and the pathology of multiple diseases. Glycobiology is a challenging research area because carbohydrates are much more complex in structure than nucleic acids and proteins and glycosylation is a highly dynamic process. In recent years, the great progress in the understanding of glycobiology and the emergence of synthetic biology methodologies has provided exciting opportunities for embedding the principles of glycobiology into synthetic biology, and the methodologies of synthetic biology into glycobiology.

Diverse synthetic biology tools have been applied to the redesign of glycosylation systems to obtain defined glycosylation patterns. These efforts raise the prospect of applying synthetic biology approaches to reengineer these systems for a variety of applications in medicine, diagnostics, and materials. The emerging field of 'synthetic glycobiology' can thus be defined as the redesign of carbohydrates, carbohydrate-binding proteins, and carbohydrate-active enzymes for new and useful purposes. Synthetic glycobiology has become a highly modular and simplified framework for studying, prototyping, and engineering pathways for glycan biosynthesis and biomolecule glycosylation. It has become a promising set of tools and techniques for accelerating basic glycobiology research and its applications.

Figure 1. Parts, systems, and applications of synthetic glycobiology. (Kightlinger W, et al., 2020)

Applications

Our Solutions

CD Biosynsis offers integrated synthetic glycobiology solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their synthetic biology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Kightlinger W, et al. Synthetic Glycobiology: Parts, Systems, and Applications. ACS Synthetic Biology, 2020, 9, 1534-1562
2. DeLisa M P, et al. Cell-free synthetic glycobiology: designing and engineering glycomolecules outside of living cells. Frontiers in Chemistry, 2020, 8: 645.

Please note that all services are for research use only. Not intended for any clinical use.