Synthetic Virology

CD Biosynsis offers customized solutions for synthetic virology to help researchers around the world facilitate their cutting-edge research and overcome the challenges. We provide advanced techniques and powerful tools to help our customers solve any problems encountered in their projects and bring breakthrough ideas to fruition.

Introduction to Synthetic Virology

Unprecedented advances in sequencing technology and oligonucleotide synthesis are at the heart of the transformation of molecular biology and the emergence of synthetic biology. This has paved the way for the construction of synthetic genomes based on previously sequenced genomes, allowing purposeful, large-scale genetic alteration of organisms. The multiple tropisms and diverse biological properties of viruses are encoded in their minimalist nucleic acid genomes. Whether synthesizing DNA or RNA viruses, it is not the entire virus initially synthesized but rather its genome. Genome synthesis independent of a natural template makes it possible to modify the structure and function of virus’ genetic information in ways that were hitherto impossible. The de novo synthesis of viral genomes in the absence of a natural template has found its way into viral research.

Synthetic virology, a branch of virology, is an emerging research field that borrows and integrates concepts and methods from a variety of disciplines, including virology, synthetic biology, nanotechnology, and computational biology. Specifically, synthetic virology aims to utilize the knowledge accumulated from fundamental virology research to reprogram naturally occurring viruses into controllable and predictable devices. This field focuses on the study and engineering of synthetic viruses and consists of two main directions: the engineering of the genetic programs encoded by the viral genome and the engineering of virus capsid. Therefore, a major goal of synthetic virology is to rewrite the details of which biomolecular features viruses use during infection. In the future, large-scale changes will be introduced into numerous viruses, allowing the creation of redesigned particles that will provide new insights into biology.

Figure 1. Synthetic virology aims to engineer viruses for gene delivery through the incorporation of natural or synthetic parts. (Guenther C M, et al., 2014)

Applications

Our Solutions

CD Biosynsis offers integrated solutions for specific purposes and a wide range of applications to help customers overcome the challenges of their synthetic virology projects.

CD Biosynsis is committed to developing services and products that cover a wide range of steps in the synthetic biology workflow. We are confident in the validity and reproducibility of the results we deliver because all of our services and products are based on reliable technologies and optimized protocols to meet high standards.

To start your synthetic biology projects, please feel free to contact us for more details. Our experienced scientific team of biologists, bioinformatics, and chemists are available for on-demand customer assistance to help you with any concerns you may have.

References

1. Guenther C M, et al. Synthetic virology: engineering viruses for gene delivery. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2014, 6(6): 548-558.
2. tenOever B R. Synthetic Virology: Building Viruses to Better Understand Them. Cold Spring Harbor Perspectives in Medicine, 2020, 10(11): a038703.

Please note that all services are for research use only. Not intended for any clinical use.