Strain Engineering for Fibrous Protein

CD Biosynsis leverages our synthetic biology platform to help our customers explore efficient ways of producing fibrous proteins to meet their growing needs in a multitude of applications. Our dedicated scientists can develop customized synthetic biology solutions to break the limits in the production and application of fibrous proteins.

Background

Fibrous proteins, also known as scleroproteins, are usually composed of fibrillar or elongated polypeptide chains and contain many superfamilies, including keratin, collagen, elastin, silk fibroins, and fibronectin. The demand for fibrous proteins is increasing in the global commercial market due to their promising applications in numerous fields such as biomedicine, pharmaceuticals, food processing, and cosmetics. However, due to the various difficulties faced in the production of fibrous proteins, the potential applications based on fibrous proteins are still under-exploited. Therefore, there is an urgent need to find robust methods to optimize the production of fibrous proteins. The powerful combination of protein synthetic biology, mammalian synthetic biology, microbial synthetic biology, and cell-free synthetic biology promises to address the challenges in fibrous protein production and create the conditions for the design and development of fibrous proteins with specific structures and functions. Our experienced scientists are dedicated to harnessing the power of synthetic biology to advance the widespread use of fibrous proteins.

Figure 1. Protein synthetic biologists assemble artificial fusion proteins from reusable segments—or parts. (Grünberg R, et al., 2010)

What We Provide

Based on the synthetic biology platform, our scientists are able to help our customers achieve fibrous protein biosynthesis using tools such as genetic engineering, protein engineering, enzyme engineering, and cellular engineering. We are committed to working with our customers to overcome challenges in the production of fibrous proteins.

Key Technologies

Deliverables

• Excellent cell factory or cell-free system for fibrous protein production.
• High-quality fibrous protein products, including collagen, elastin, and silk fibroins.

How We Can Help

CD Biosynsis offers our expertise and experience in protein synthetic biology to help our customers realize the great potential of fibrous proteins in a variety of applications. Our distinguished scientists are dedicated to providing customized solutions to overcome all the difficulties in the production and application of different types of fibrous protein. The services we can provide are as follows. If you would like to learn more about the specific issues we can help you with based on the following service offerings, please contact us directly or fill out the online form.

• We are able to provide custom fibrous protein expression services in E. coli.
• We have constructed a baculovirus recombinant protein expression system that is capable of meeting our customers' needs for rapid, large-scale fibrous protein production.
• We have constructed a recombinant protein expression system for mammalian cells that can help our customers achieve the expression and purification of fibrous protein in mammalian cells.
• We are able to provide fibrous protein expression services in yeast cells.
• We are able to provide peptide synthesis services to meet the individual needs of our customers.
• Leveraging our expertise in cell-free synthetic biology and metabolic engineering, our exceptional scientists can help our customers develop one-stop cell-free synthetic systems for fibrous protein production to enhance production efficiency and yield.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in protein and peptide production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

1. Grünberg R; Serrano L. Strategies for protein synthetic biology. Nucleic Acids Res, 2010, 38(8):2663-75.
2. Sorushanova A, et al. The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Adv Mater, 2019, 31(1): e1801651.

Please note that all services are for research use only. Not intended for any clinical use.