Strain Engineering for Collagen

CD Biosynsis has established a comprehensive synthetic biology platform to help our customers develop effective synthetic biology strategies to optimize the biological production pathway of collagens. We are committed to removing all obstacles encountered in producing collagen and promoting the widespread application of collagen in the biomedical, pharmaceutical, food, and cosmetic fields.

Advantages of Synthetic Biology-Driven Collagen Production

Collagen is the most abundant protein in the human body and has a wide range of applications in the food, cosmetic, pharmaceutical, and biomedical industries. Currently, the main way to obtain collagen is by extracting it from animal tissues. However, collagen obtained in this manner has many limitations in its application and there are problems associated with animal-derived materials such as immunogenicity and cross-species transmission of disease. These concerns and issues have stimulated enthusiasm for the development of cellular and microbial factories for collagen production. The revolutionary technology of synthetic biology has unprecedented capabilities in the design and construction of microbial and cellular factories for collagen production, which will greatly advance the use of collagen in a wide range of applications.

Figure 1. Schematic representation of recombinant bacterial collagen construct. (Brodsky B, et al., 2017)

What We Provide

CD Biosynsis has established a multidisciplinary team with expertise and experience in synthetic biology, genetic engineering, and protein engineering to help our customers develop effective solutions to overcome all difficulties in the production and application of collagens. Our dedicated and highly creative scientists can develop customized collagen production processes based on our customers' specific downstream application needs in order to drive large-scale applications of collagen in a wide range of fields.

Deliverables

• Excellent cell factory for collagen production.
• High-quality collagen products.

How We Can Help

Microbial Chassis Development for Collagen Production

Leveraging our advanced technologies in bacterial synthetic biology and fungal synthetic biology, we can help our customers directionally design and modify microbial chassis to create engineered microorganisms with excellent collagen production performance. Our experienced scientists can optimize the biosynthetic pathway of collagen to increase yield and productivity. The following are the microbial strains that we have developed for collagen production. If you are interested in other strains, please fill out the online inquiry form and tell us more about your project.

Construction of a Cell Factory for Collagen Production

Many primary and immortalized cells have been used to produce various types of collagens from a variety of species. however, cell-based approaches to collagen production have yielded very limited proteins. Leveraging our advanced technology in the field of cellular synthetic biology, our specialized scientists can harness innovative thinking based on engineering principles to program living cells using artificial genetic circuits to develop cells with powerful biosynthetic activity and rapid growth. We are committed to helping our customers establish efficient cell factories for collagen production, including but not limited to plant cell factories, mammalian cell factories, and insect cell factories. If you are interested in our Cell & Tissue Engineering services, please fill out our online inquiry form and tell us more about your project.

Incorporation of Non-Natural Amino Acids

Non-natural amino acids can exhibit structures and functions not found in 20 natural amino acids, offering the possibility of enhanced protein function or the generation of new protein properties. We achieve in vivo specific incorporation of non-natural amino acids by gene encoding insertion of non-natural amino acids.

Applications of Collagens

CD Biosynsis offers our expertise and experience in protein synthetic biology to help our customers realize the great potential of collagens in a variety of applications.

• Used as oral collagen supplementation.
• Used as a functional antioxidant and antibacterial ingredient in food supplements.
• Used as anticoagulant.
• Used in the processing and production of meat and beverages.
• Used in the development of biomaterials for tissue engineering and clinical applications.
• Used in drug delivery.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in protein and peptide production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

1. Brodsky B; Ramshaw JA. Bioengineered Collagens. Subcell Biochem. 2017, 82: 601-629.
2. Sorushanova A, et al. The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Adv Mater. 2019, 31(1): e1801651.

Please note that all services are for research use only. Not intended for any clinical use.