Strain Engineering for Amylase

CD Biosynsis leverages our advanced platform and expertise in synthetic biology to help our customers overcome the challenges of traditional amylase production to meet the growing demand for amylases in various fields including the food industry and textile industry. We pursue efficient and cost-effective production of amylases to drive their widespread use in industrial production.

Advantages of Synthetic Biology-Driven Amylases Production

Amylases are starch hydrolyzing enzymes which are classified as exo-amylase and endo-amylase that act on α-1,4- and α-1,6-glucosidic bonds of starch and glycogen. Currently, amylase is widely applicated in the food, detergent, paper, pharmaceutical, and textile industries. However, the development of conventional amylase production faces many challenges, among which the functional specificity and stability of the enzyme are the main issues in the commercialization process. In addition, the efficiency, cost-effectiveness and environmental friendliness of amylase production are also of major concern. With the development of synthetic biology techniques, the production of microbial amylases has successfully replaced the production of chemical processes. Recent advances in synthetic biology have led to breakthroughs in the development of high-quality amylase-producing microorganisms through genetic and metabolic engineering strategies. Synthetic biology provides new ways to significantly improve the functional specificity and enzyme stability of amylases, thus helping to achieve large-scale, efficient, and ultra-environmentally friendly industrial production of amylases. 

Figure 1. Three-dimensional structures of amylases. (a) α-Amylase. (b) β-Amylase. (Gopinath SC, et al., 2017) 

What We Provide

Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of amylases.

Deliverables

• Amylase-producing microorganisms.
• High-quality amylase products, including alpha-amylase, beta-amylase, and gamma-amylase.

How We Can Help

CD Biosynsis offers our advanced technology and extensive experience to help our customers develop synthetic biology strategies for efficient and cost-effective amylase production. Our scientists can develop customized optimization strategies based on our customer requirements for amylase production and application scenarios.

Development of Synthetic Biology Chassis for Amylase Production

Our expertise and advanced technologies in bacterial synthetic biology, fungal synthetic biology and algal synthetic biology allow us to develop effective genetic tools and metabolic engineering strategies that enable different types of microorganisms to obtain desirable properties and become ideal chassis for the production of amylases suitable for different application scenarios. We work to enhance the physical and chemical parameters of amylases for industrial use through synthetic biology in order to break the limitations of amylases in practical applications. The following are the amylase-producing microorganisms including bacteria and fungi that we are capable of developing as synthetic biology chassis. If you are interested in other microbial strains, please fill out the online inquiry form and tell us more about your project.

Overcome Challenges in Amylases Production

• Low activity
  We can use powerful synthetic biology tools to specifically modify amylases to improve enzyme activity.
• Low production efficiency
  We can develop synthetic biology-based microbial engineering strategies for efficient production of amylases.
• Low functionality and stability
  We can help develop strategies for mutagenesis and cloning to produce engineered amylases with improved functionality and stability.

Applications of Amylase

CD Biosynsis provides customized solutions for synthetic biology-driven amylase production to meet a wide range of applications in laboratory and industrial production.

Applications of amylase in the food industry

• Used as a flavor enhancer and preservative to improve bread quality.
• Used in the pretreatment of animal feed to improve fiber digestibility.
• Used in the production of beer or juice.

Application of amylase in the detergent field

• Alpha-amylase is added to dishwashers and mandatory detergents to improve washing efficiency.

Application of amylase in the textile industry

• Used in the production process of textile materials.

Want to Learn More?

As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for industrial enzyme production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

1. Shukla P. Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications. Indian J Microbiol. 2019, 59(4): 401-409.
2. Gopinath SC, et al. Biotechnological Processes in Microbial Amylase Production. Biomed Res Int, 2017, 2017: 1272193.

Please note that all services are for research use only. Not intended for any clinical use.