Strain Engineering for Laccase

What We Provide

CD Biosynsis' advanced synthetic biology platform and extensive expertise allows us to help our customers develop customized and effective strategies to achieve improved production of laccases.

Featured Services

Isolation, identification, and selection of suitable host organisms to improve laccase production.
Development of heterologous expression systems to achieve high-yield and high-purity and high-stability of laccase production and eliminate unwanted activities.
Development of synthetic biology-based strategies for laccase engineering to produce enzymes with desired properties for specific industrial needs.

Key Strategies and Technologies

Deliverables

Laccase-producing organisms.
High-quality laccase products, including fungal laccases, plant laccases, and bacterial laccases.

How We Can Help

CD Biosynsis provides our advanced platform and extensive experience in synthetic biology to help our customers customize highly active and stable laccase for their target substrates, and achieve large-scale, high-efficiency laccase production. In addition, our scientists can develop effective strategies to further improve the yield and efficiency of laccase production.

Development of Synthetic Biology Chassis for Laccase Production

Cartoon structures of the three-domain laccase from Bacillus subtilis.

Our advanced technologies and extensive experience in bacterial synthetic biology, fungal synthetic biology, and plant synthetic biology have enabled us to develop effective genetic tools and metabolic engineering strategies to enable different types of microorganisms or plants to obtain desirable properties and to become the ideal chassis for the production of laccase enzymes adapted to various application scenarios. We focus on every problem faced in laccase production and application and are committed to developing laccase with exciting and tailored biotechnological properties to overcome these challenges through emerging synthetic biology technologies. The following are some of the bacteria, fungi and plants that have the potential to be developed as synthetic biology chassis. If you are interested in other organisms, please fill out our online inquiry form and tell us more about your project.

Asparagus densiflorus	Aspergillus niger	Aspergillus oryzae	Bacillus halodurans	Bacillus tequilensis
Escherichia coli	Klebsiella	Marinomonas mediterranea	Nicotiana tabacum	Pichia pastoris
Proteobacterium	Pseudomonas	Streptomyces coelicolor	Trichoderma atroviride	Yersinia

Improvement of Laccase Production

To improve laccase production and its properties, we can help develop effective synthetic biology-based strategies, including but not limited to:

Development of chimeric laccases with combined characteristics in terms of substrate affinity, pH activity, and thermal stability.
Engineering of laccases by replacing hydrophilic residues with hydrophobic residues to improve their stability in organic solvents.

Applications of Laccase

CD Biosynsis provides customized solutions for synthetic biology-driven laccase production to meet a wide range of applications including bioremediation and industrial production.

Applications of laccase in the food industry

Use of laccase to add color and flavor to wines.
Use of laccase to extend the storage life of beer.

Applications of laccase in bioremediation and biodegradation

Use of laccase to degrade pesticide and herbicide residues in soil.
Use of laccase to break down harmful benzene, polychlorinated biphenyls (PCBs) and toluene in the environment.

Application of laccase in the nanobiotechnology

Use of laccase to develop nanobiosensors.

Want to Learn More?

As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for industrial enzyme production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

Shukla P. Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications. Indian J Microbiol, 2019, 59(4): 401-409.
Arregui L, et al. Laccases: structure, function, and potential application in water bioremediation. Microb Cell Fact, 2019, 18(1): 200.
Bertrand B, et al. Upgrading Laccase Production and Biochemical Properties: Strategies and Challenges. Biotechnol Prog, 2017, 33(4): 1015-1034.

Please note that all services are for research use only. Not intended for any clinical use.

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